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Rapsyn antibody [1234]

Cat. No. GTX11423

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 1234

Isotype

 IgG1

Application

 WB, ICC/IF, IHC-Fr

Reactivity

 Mouse, Rat, Chicken, Amphibians, Fish
Package
50 μg ($399)
See all Rapsyn products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5 μg/ml
ICC/IF 2 μg/ml
IHC-Fr Assay dependent
Not tested in other applications.

Calculated MW

46 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

Whole purified rapsyn from Torpedo californica electric organ postsynaptic membrane.

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

receptor-associated protein of the synapse , 43kDa , Nraps , Raps , rapsyn

Cellular Localization

Cytoplasm, cytoskeleton

Background

Nicotinic acetylcholine receptors (AChRs) are organized into high-density postsynaptic clusters at the motor endplate that are critical for efficient synaptic transmission. The organization of AChR’s is carried out by the 43 kDa cytoplasmic protein rapsyn. Studies have indicated that mutations which impair the activity of rapsyn can lead to the formation of congenital myasthenic syndrome (CMS). CMS is characterized by poor development of the postsynaptic region.

Database

Research Area

REFERENCE

Application Reference

T Meier et al. J Neurosci 1997; 17 (17) : 6534–6544 Neural Agrin Induces Ectopic Postsynaptic Specializations in Innervated Muscle Fibers
Application : ICC/IF
G Feng et al. J Neurosci 1988; 18 (11) : 4166–4176 Rapsyn Clusters Neuronal Acetylcholine Receptors But Is Inessential for Formation of an Interneuronal Cholinergic Synapse
Application : IHC-Fr
Reactivity : Mouse
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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399