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Rb2 / p130 antibody [130P211 (same as DCS211)]

Cat No. GTX72409

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 130P211 (same as DCS211)

Isotype

 IgG1

Application

 ICC/IF

Reactivity

 Human
Package
500 μl ($319)
See all Rb2 / p130 products

APPLICATION

Application Note

Immunofluorescence. Optimal dilution should be determined by researcher.

Positive Control

Jurkat Cells

PROPERTIES

Form

Liquid

Buffer

200ug/ml of antibody purified from ascites fluid by Protein G chromatography. Prepared in 10mM PBS, pH 7.4, with 0.2% BSA and 15mM sodium azide. Also available without BSA and azide at 1mg/ml.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Immunogen

A synthetic peptide from Rb2 / p130 corresponding to aa878-913

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Cellular Localization

Cytoplasmic

Background

Two retinoblastoma-related proteins, p107 and pRb2/p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb/p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the ""pocket domain."" Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2/p130, which may suggest an important role forThis protein in the pathogenesis and progression of lung cancer.

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 319