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Rb2 / p130 antibody [KAB40]

Cat No. GTX10576

Host Mouse
Clonality Monoclonal
Clone Name KAB40
Isotype IgG1
Application WB
Reactivity Human, Mouse, Donkey
Package
50 μg ($319)
APPLICATION

Application Note

WB: Use at a dilution of 1/1000. Detects a band of approximately 130 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

128 kDa. ( Note )

Positive Control

CC3A whole cell lysate

Specificity/Sensitivity

Recognizes both phosphorylated and non-phosphorylated forms of Rb2 / p130 by immunoblotting.
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.2, containing 0.08% Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein (Human).

Purification

Protein G purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Rb Transcriptional Corepressor Like 2 , P130 , Rb2 , Rbl2

Cellular Localization

Nuclear

Background

Two retinoblastoma related proteins, p107 and pRb2 / p130, which are structurally and functionally similar to the product of the retinoblastoma gene (pRb / p105), were cloned by taking advantage of their ability to bind transforming proteins of DNA tumor viruses through a particular region called the ""pocket domain."" Like pRb, both proteins play a fundamental role in growth control. These Rb family proteins were measured in a variety of lung neoplasms. The highest percentage of undetectable levels and the tightest inverse correlation with the histological grading and with PCNA expression in the most aggressive tumor types were found for pRb2 / p130, which may suggest an important role for this protein in the pathogenesis and progression of lung cancer.

Database

Research Area

REFERENCE
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Package List Price ($)
$ 319