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SATB2 antibody

Anti-SATB2 antibody used in Western Blot (WB). GTX30894
Anti-SATB2 antibody used in IHC (Paraffin sections) (IHC-P). GTX30894
Anti-SATB2 antibody used in IHC (Paraffin sections) (IHC-P). GTX30894

Cat. No. GTX30894

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
50 μg ($399)
See all SATB2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 2 - 4 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

83 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , A20 Cell Lysate(GTX27180)

Product Note

At least two isoforms of SATB2 are known to exist. This SATB2 antibody will not cross-react with SATB1.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

SATB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human SATB2.The immunogen is located within amino acids 570 - 620 of SATB2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

SATB homeobox 2 , GLSS

Background

Human special AT-rich sequence-binding protein-2 (SATB2) is a nuclear matrix/scaffold-associated region DNA-binding protein. Like its homolog SATB1, SATB2 selectively binds double-stranded, special AT-rich DNA sequences, but is expressed primarily in a subset of postmitotic, differentiating neurons in the neocortex. Mice deficient in SATB exhibit craniofacial abnormalities and defects in osteoblast differentiation and function. SATB2 also interacts with and enhances the activity of Runx2 and ATF4, two transcription factors that regulate osteoblast differentiation, indicating that SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Recent experiments have shown that SATB2 interacts with histone deacetylase 1 and metastasis-associated protein 2, two proteins that are involved in chromatin remodeling, suggesting that SATB2 may also be involved in mediating epigenetic influences during cortical development. At least two isoforms of SATB2 are known to exist.

Database

Research Area

DATA IMAGES

Anti-SATB2 antibody used in Western Blot (WB). GTX30894

GTX30894 WB Image

WB analysis of A-20 cell lysate using GTX30894 SATB2 antibody.
Working concentration : (A) 2 and (B) 4 μg/ml

Anti-SATB2 antibody used in IHC (Paraffin sections) (IHC-P). GTX30894

GTX30894 IHC-P Image

IHC-P analysis of human brain tissue using GTX30894 SATB2 antibody.
Working concentration : 5 μg/ml

Anti-SATB2 antibody used in IHC (Paraffin sections) (IHC-P). GTX30894

GTX30894 IHC-P Image

IHC-P analysis of human brain tissue using GTX30894 SATB2 antibody.
Working concentration : 50 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399