GeneTex

  • Country / Location Selection

United States (US)

SCRN1 antibody

Anti-SCRN1 antibody used in Western Blot (WB). GTX85172
Anti-SCRN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85172
Anti-SCRN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85172

Cat. No. GTX85172

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($409)
See all SCRN1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

46 kDa. ( Note )

Positive Control

Human Kidney Tissue Lysate(GTX29995) , Human Kidney Tissue Slide

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

SCRN1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human SCRN1.The immunogen is located within amino acids 320 - 370 of SCRN1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

secernin 1 , SES1

Cellular Localization

Cytoplasm

Background

SCRN1 was first identified as a cytosolic protein that is involved in the regulation of exocytosis from peritoneal mast cells. More recent studies have shown that SCRN1 expression is upregulated in gastric cancer cell lines and may possess epitopes that could function as tumor-associated antigens, potentially providing targets for cancer vaccines in the treatment of gastric cancers. Another report indicates that decreased expression of SCRN1 via RNAi expression resulted in significantly lower rates of cell growth in colorectal cancer cell lines, and increased SCRN1 expression in patients with colorectal cancer correlated with poor prognosis, suggesting that SCRN1 may also be involved in the regulation of cell growth and might be useful as a prognostic tool.

Database

Research Area

DATA IMAGES

Anti-SCRN1 antibody used in Western Blot (WB). GTX85172

GTX85172 WB Image

WB analysis of human kidney tissue lysate in (A) the absence and (B) the presence of blocking peptide using GTX85172 SCRN1 antibody.
Working concentration : 1 μg/ml

Anti-SCRN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85172

GTX85172 IHC-P Image

IHC-P analysis of human kidney tissue using GTX85172 SCRN1 antibody.
Working concentration : 20 μg/ml

Anti-SCRN1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85172

GTX85172 IHC-P Image

IHC-P analysis of human kidney tissue using GTX85172 SCRN1 antibody.
Working concentration : 5 μg/ml

REFERENCE

Application Reference

Conde-Rubio MDC et al. Cell Death Discov 2021; 7 (1) : 164 The proteolytic landscape of cells exposed to non-lethal stresses is shaped by executioner caspases.
Application : WB
Submit a Reference

REVIEW

There are currently no reviews for SCRN1 antibody (GTX85172). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 409