SEK1 / MKK4 antibody [5H4]

Cat. No. GTX60399

Host	Mouse
Clonality	Monoclonal
Clone Name	5H4
Isotype	IgG1
Application	WB, IHC-P, FACS, ELISA
Reactivity	Human
Package	100 μl ($409)

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Datasheet
Document

View product citations for antibody GTX60399 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1/500 - 1/2000
IHC-P	1/200 - 1/1000
FACS	1/200 - 1/400
ELISA	1/10000

Not tested in other applications.

Calculated MW

44 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Ascites

Preservative

0.03% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Purified recombinant fragment of human MAP2K4 expressed in E. Coli.

Purification

Unpurified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

mitogen-activated protein kinase kinase 4 , JNKK , JNKK1 , MAPKK4 , MEK4 , MKK4 , PRKMK4 , SAPKK-1 , SAPKK1 , SEK1 , SERK1 , SKK1

Cellular Localization

Cytoplasm,Nucleus

Background

This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver. [provided by RefSeq, Jul 2008]

Database

Gene ID: 6416 MAP2K4
UniProt: P45985 MAP2K4

Research Area

DATA IMAGES

GTX60399 WB Image

WB analysis of HepG2 (1), K562 (2), and HEK293 (3) cell lysate using GTX60399 SEK1 / MKK4 antibody [5H4].

GTX60399 IHC-P Image

IHC-P analysis of human muscle tissue using GTX60399 SEK1 / MKK4 antibody [5H4].

GTX60399 FACS Image

FACS analysis of K562 cells using GTX60399 SEK1 / MKK4 antibody [5H4].
Green : SEK1 / MKK4
Purple : negative control

GTX60399 ELISA Image

ELISA analysis of antigen using GTX60399 SEK1 / MKK4 antibody [5H4].
Red : Control antigen 100ng
Purple : Antigen 10ng
Green : Antigen 50ng
Blue : Antigen 100ng

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf

Package

List Price ($)

100 μl

$ 409

Qty