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SHP1 (phospho Tyr536) antibody

Anti-SHP1 (phospho Tyr536) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX50327
Anti-SHP1 (phospho Tyr536) antibody used in IHC (Paraffin sections) (IHC-P). GTX50327

Cat No. GTX50327

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

ICC/IF, IHC-P

Reactivity

Human
Package
100 μl ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF 1:100-1:200
IHC-P 1:50-1:100
Not tested in other applications.

Calculated MW

68 kDa. ( Note )

Predict Reactivity

Mouse, Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH 7.4, 150mM NaCl, 0.02% sodium azide, 50% glycerol

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide sequence around phosphorylation site of tyrosine 536 (S-E-Y(p)-G-N) derived from human SHP1.

Purification

Purified by antigen-affinity chromatography. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

protein tyrosine phosphatase non-receptor type 6 , HCP , HCPH , HPTP1C , PTP-1C , SH-PTP1 , SHP-1 , SHP-1L , SHP1

Cellular Localization

Cytoplasm,Nucleus

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-SHP1 (phospho Tyr536) antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX50327

GTX50327 ICC/IF Image

ICC/IF analysis of methanol-fixed HeLa cells using GTX50327 SHP1 (phospho Tyr536) antibody.

Anti-SHP1 (phospho Tyr536) antibody used in IHC (Paraffin sections) (IHC-P). GTX50327

GTX50327 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX50327 SHP1 (phospho Tyr536) antibody.
Left : Primary antibody
Right : Primary antibody pre-incubated with the antigen specific peptide

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf