GeneTex
United States (US)

SHP2 antibody

GTX31744_2905_WB_20180221_18121410_283.jpg

Cat No. GTX31744

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ELISA
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5 - 2 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

68 kDa. ( Note )

Positive Control

Mouse Skeletal Muscle Tissue Lysate(GTX27938)
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

SHP2 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human SHP2.The immunogen is located within amino acids 510 - 560 of SHP2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Protein Tyrosine Phosphatase, Non-Receptor Type 11,Bptp3,Cfc,Jmml,Metcds,Ns1,Ptp-1D,Ptp2C,Sh-Ptp2,Sh-Ptp3,Shp2,Ptpn11

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Database

Research Area

DATA IMAGES
GTX31744_2905_WB_20180221_18121410_283.jpg

GTX31744 WB Image

WB analysis of mouse skeletal muscle tissue lysate using GTX31744 SHP2 antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml

Package List Price ($)
$ 329