1XPBS, 40% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.)
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human SIPA1. The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
MGC102688 antibody, MGC17037 antibody, SPA1 antibody, SIPA1 antibody, p130 SPA-1 antibody, sipa-1 antibody, GTPase-activating protein Spa-1 antibody, signal-induced proliferation-associated protein 1 antibody, signal-induced proliferation-associated gene 1 antibody, signal-induced proliferation-associated 1 antibody
Nucleus , Cytoplasm , perinuclear region , Endomembrane system; Peripheral membrane protein
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq]