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SIRP alpha antibody [MRC OX-41] (Biotin)

Cat No. GTX76051

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 MRC OX-41

Isotype

 IgG2a

Application

 ICC/IF, FACS, RIA

Reactivity

 Rat
Package
100 μg ($319)
See all SIRP alpha products

APPLICATION

Application Note

For FACS: Use at an assay dependent dilution. For ICC: Use at an assay dependent dilution. For IF: Use at an assay dependent dilution. For RIA (indirect): Use at an assay dependent dilution. Not tested in other species. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

56 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, containing 0.02% sodium azide and 0.5% BSA

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Rat peritoneal macrophages

Purification

Protein G purified

Conjugation

Biotin

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

Signal-Regulatory Protein Alpha , Bit , Ptpns1 , Shps-1 , Sirpa

Background

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. May play a role in the release of nitric oxide by macrophages.

Database

Research Area

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 319