APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
Application |
Dilution |
1 - 2 μg/mL |
2.5 μg/mL |
Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Human Brain Tissue Slide(GTX22203) , Mouse Brain Tissue Lysate(GTX27934)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
SIRT2 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of the human SIRT2.The immunogen is located within the last 50 amino acids of SIRT2.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
sirtuin 2 , SIR2 , SIR2L , SIR2L2
Cellular Localization
Nucleus,Cytoplasm,Cytoplasm, cytoskeleton
Background
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Database
Research Area
DATA IMAGES
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GTX31335 WB Image
WB analysis of mouse brain tissue lysate using GTX31335 SIRT2 antibody. Working concentration : (A) 1 and (B) 2 μg/ml
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GTX31335 IHC-P Image
IHC-P analysis of human brain tissue using GTX31335 SIRT2 antibody. Working concentration : 2.5 μg/ml
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GTX31335 IHC-P Image
IHC-P analysis of human brain tissue using GTX31335 SIRT2 antibody. Working concentration : 5 μg/ml
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REFERENCE
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REVIEW
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