APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 μg/mL |
| 2.5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Human Brain Tissue Slide(GTX22203) , Mouse Brain Tissue Lysate(GTX27934)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
ZIP2 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human ZIP2.The immunogen is located within amino acids 70 - 120 of ZIP2.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
solute carrier family 39 member 2 , 6A1 , ETI-1 , ZIP-2 , ZIP2
Cellular Localization
Cell membrane; Multi-pass membrane protein
Background
The zinc transporter ZIP2, also known as SLC39A2, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. Similar to knock-outs of ZIP1 and ZIP3, ZIP2- mice have no phenotypic differences compared to wild-type mice. Only when ZIP1, ZIP2, and ZIP3 genes are all eliminated and these mutant mice are fed a zinc-deficient diet do abnormalities such as reduced embryonic-membrane bound alkaline phosphatase activity and abnormal development occur, indicating that the ZIP1-3 proteins play an important, noncompensatory role when zinc is deficient. More recent studies have shown that ZIP2 and ZIP3 are down regulated in human prostate adenocarcinomatous glands, and may be important in the retention of zinc in the cellular compartment.
Database
Research Area
DATA IMAGES
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GTX85134 IHC-P Image
IHC-P analysis of human brain tissue using GTX85134 SLC39A2 antibody.
Working concentration : 2.5 μg/ml
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GTX85134 IHC-P Image
IHC-P analysis of human brain tissue using GTX85134 SLC39A2 antibody.
Working concentration : 20 μg/ml
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GTX85134 WB Image
WB analysis of (A) mouse and (B) rat brain tissue lysate using GTX85134 SLC39A2 antibody.
Working concentration : 1 μg/ml
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REFERENCE
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REVIEW
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