GeneTex
United States (US)

SMC1 antibody [C2M]

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Cat No. GTX16147

Host Mouse
Clonality Monoclonal
Clone Name C2M
Isotype IgG
Application WB
Reactivity Human
APPLICATION

Application Note

WB: Use at a concentration of 1 - 5 μg/ml. Detects a band of approximately 166 kDa (predicted molecular weight: 143 kDa). Optimal dilutions/concentrations should be determined by the end user.

Positive Control

HeLa cells
PROPERTIES

Form

Liquid

Buffer

Preservative: 0.08% Sodium Azide; Constituents: PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment, corresponding to amino acids 402-894 of Human SMC1.

Purification

IgG fraction

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

SMCB Antibody , SMC1ALPHA Antibody , SMC1A Antibody , DXS423E Antibody , SMC1L1 Antibody , SB1.8 Antibody , CDLS2 Antibody

Cellular Localization

Nuclear

Background

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. [provided by RefSeq, Jul 2008]
DATA IMAGES
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GTX16147 WB Image

SMC1 antibody [C2M]

Package List Price ($)
$ 329