GeneTex
  • Country / Location Selection

United States (US)

SMN2 antibody

Anti-SMN2 antibody used in Western Blot (WB). GTX32884
Anti-SMN2 antibody used in IHC (Paraffin sections) (IHC-P). GTX32884
Anti-SMN2 antibody used in IHC (Paraffin sections) (IHC-P). GTX32884
Anti-SMN2 antibody used in IHC (Paraffin sections) (IHC-P). GTX32884

Cat No. GTX32884

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human, Mouse, Rat
Package
100 μl ($319)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:2000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

32 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS pH7.3, 0.02% sodium azide, 50% glycerol.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-197 of human SMN2 (NP_059107.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

survival of motor neuron 2, centromeric , BCD541 , C-BCD541 , GEMIN1 , SMNC , TDRD16B

Cellular Localization

Cytoplasm

Background

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein. While mutations in the telomeric copy are associated with spinal muscular atrophy, mutations in this gene, the centromeric copy, do not lead to disease. This gene may be a modifier of disease caused by mutation in the telomeric copy. The critical sequence difference between the two genes is a single nucleotide in exon 7, which is thought to be an exon splice enhancer. Note that the nine exons of both the telomeric and centromeric copies are designated historically as exon 1, 2a, 2b, and 3-8. It is thought that gene conversion events may involve the two genes, leading to varying copy numbers of each gene. The full length protein encoded by this gene localizes to both the cytoplasm and the nucleus. Within the nucleus, the protein localizes to subnuclear bodies called gems which are found near coiled bodies containing high concentrations of small ribonucleoproteins (snRNPs). This protein forms heteromeric complexes with proteins such as SIP1 and GEMIN4, and also interacts with several proteins known to be involved in the biogenesis of snRNPs, such as hnRNP U protein and the small nucleolar RNA binding protein. Four transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Sep 2008]

Database

Research Area

DATA IMAGES
Anti-SMN2 antibody used in Western Blot (WB). GTX32884

GTX32884 WB Image

WB analysis of various samples using GTX32884 SMN2 antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-SMN2 antibody used in IHC (Paraffin sections) (IHC-P). GTX32884

GTX32884 IHC-P Image

IHC-P analysis of rat heart tissue using GTX32884 SMN2 antibody.

Anti-SMN2 antibody used in IHC (Paraffin sections) (IHC-P). GTX32884

GTX32884 IHC-P Image

IHC-P analysis of mouse liver tissue using GTX32884 SMN2 antibody.

Anti-SMN2 antibody used in IHC (Paraffin sections) (IHC-P). GTX32884

GTX32884 IHC-P Image

IHC-P analysis of human prostate tissue using GTX32884 SMN2 antibody.

REFERENCE
There are currently no references for SMN2 antibody (GTX32884). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for SMN2 antibody (GTX32884). Be the first to share your experience with this product.
Package List Price ($)
$ 319