Phosphate-buffered saline, pH 7.4, containing no preservatives
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Batch dependent (Please refer to the vial label for the specific concentration.)
A synthetic peptide from the human SMRT protein corresponding to amino acids 80-92 (QELHLRPESHSYL).
Protein G Affinity Purified
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Nuclear Receptor Corepressor 2 , Ctg26 , N-Cor2 , Smap270 , Smrt , Smrte , Smrte-Tau , Tnrc14 , Trac , Trac-1 , Trac1 , Ncor2
GTX70245 recognizes the Silencing Mediator for Retinoid and Thyroid receptors (SMRT) gene product, a 168 kDa nuclear protein. Nuclear hormone receptors are transcription factors regulated by ligand binding. In the absence of ligand there is a physical interaction between the nuclear receptors that do not interact with Hsp90 and a family of corepressors which includes SMRT. SMRT helps target histone deacetylases and other components of a multiprotein repressor complex to the specific target promoter to silence gene transcription.