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SON antibody

Anti-SON antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX129778

Cat. No. GTX129778

Reference 5

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 ICC/IF

Reactivity

 Human
Package
100 μl ($399),
25 μl ($169)
See all SON products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF 1:100-1:1000
Not tested in other applications.

Calculated MW

264 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human SON. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_2886086

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

SON DNA binding protein , BASS1 , C21orf50 , DBP-5 , NREBP , SON3 , TOKIMS

Cellular Localization

Nucleus speckle

Background

The protein encoded by this gene binds to a specific DNA sequence upstream of the upstream regulatory sequence of the core promoter and second enhancer of human hepatitis B virus (HBV). Through this binding, it represses HBV core promoter activity, transcription of HBV genes, and production of HBV virions. The protein shows sequence similarities with other DNA-binding structural proteins such as gallin, oncoproteins of the MYC family, and the oncoprotein MOS. It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. Several transcript variants encoding different isoforms have been described for this gene, but the full-length nature of only two of them has been determined. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-SON antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX129778

GTX129778 ICC/IF Image

SON antibody detects SON protein at nucleus by immunofluorescent analysis.
Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: SON protein stained by SON antibody (GTX129778) diluted at 1:500.
Blue: Hoechst 33342 staining.

REFERENCE

Application Reference

Y Xie et al. Cell Rep 2023; 42 (8) : 112988 Structural basis for high-order complex of SARNP and DDX39B to facilitate mRNP assembly
Application : ICC/IF
Reactivity : Human
Gao S et al. Proc Natl Acad Sci U S A 2022; 119 (25) : e2206046119 Nuclear speckle integrity and function require TAO2 kinase.
Aksenova V et al. Nat Commun 2020; 11 (1) : 4577 Nucleoporin TPR is an integral component of the TREX-2 mRNA export pathway.
Application : ICC/IF
Reactivity : Human
Vasilisa Aksenova et al. bioRxiv 2019; (Epub) Distinct Basket Nucleoporins roles in Nuclear Pore Function and Gene Expression: Tpr is an integral component of the TREX-2 mRNA export pathway.
Reactivity : Human
Mor A et al. Nat Microbiol 2016; 1 (7) : 16069 Influenza virus mRNA trafficking through host nuclear speckles.
Submit a Reference

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SDS
PBS.pdf
Glycerol.pdf
Proclin.pdf
Package List Price ($)
$ 399
$ 169