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SOX10 antibody [SPM607]

Anti-SOX10 antibody [SPM607] used in IHC (Paraffin sections) (IHC-P). GTX35085

Cat. No. GTX35085

Reference 2

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 SPM607

Isotype

 IgG2b

Application

 WB, ICC/IF, IHC-P, FACS

Reactivity

 Human
Package
100 μg ($529)
See all SOX10 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1-2μg/ml
ICC/IF 1-2μg/ml
IHC-P 1-2μg/ml for 30 minutes at RT
FACS 1-2μg/10⁶ cells

Note :

IHC-P
Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95ºC followed by cooling at RT for 20 minutes.
Not tested in other applications.

Calculated MW

50 kDa. ( Note )

Product Note

This MAb is highly specific and does not cross-react with other members of the SOX-family.

PROPERTIES

Form

Liquid

Buffer

PBS, 0.05% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.2 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fragment (aa 115-269) of human SOX10 protein with hexa-histidine tag

Purification

Protein A/G purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

DOM , PCWH , SOX10 , SRYbox 10 , WS2E , WS4 , WS4C , SRY-box transcription factor 10

Cellular Localization

Cytoplasm,Nucleus,Mitochondrion outer membrane

Background

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-SOX10 antibody [SPM607] used in IHC (Paraffin sections) (IHC-P). GTX35085

GTX35085 IHC-P Image

IHC-P analysis of human melanoma tissue using GTX35085 SOX10 antibody [SPM607].

REFERENCE

Application Reference

J Jin et al. Research Square 2024; Investigating Spontaneous Regression in Large Congenital Melanocytic Nevus: A Single-Cell Transcriptomic Study
Wei B et al. J Immunol Res 2021; 2021 : 8512200 Transcriptome Analysis of Large to Giant Congenital Melanocytic Nevus Reveals Cell Cycle Arrest and Immune Evasion: Identifying Potential Targets for Treatment.
Application : IHC-P
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 529