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SOX2 antibody [N1C3]

KO/KD Comparison Orthogonal
Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507
Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507
Anti-SOX2 antibody [N1C3] used in IHC (Frozen sections) (IHC-Fr). GTX101507
Anti-SOX2 antibody [N1C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX101507
Anti-SOX2 antibody [N1C3] used in Flow cytometry (FACS). GTX101507
Anti-SOX2 antibody [N1C3] used in IHC (Frozen sections) (IHC-Fr). GTX101507
Anti-SOX2 antibody [N1C3] used in Immunoprecipitation (IP). GTX101507
Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507
Anti-SOX2 antibody [N1C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX101507
Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507
Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507
Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507
Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507
Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507
Anti-SOX2 antibody [N1C3] used in Immunoprecipitation (IP). GTX101507
Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507
Anti-SOX2 antibody [N1C3] used in IHC (Frozen sections) (IHC-Fr). GTX101507
Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507
Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507
Anti-SOX2 antibody [N1C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX101507
Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507

Cat No. GTX101507

Reference 57
12

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IHC-Fr, FACS, IP

Reactivity

 Human, Mouse, Rat, Frog, Ceratotherium simum
Package
100 μl ($329),
25 μl ($169)
See all SOX2 products
PRODUCT

Summary

SOX2 antibody detects SOX2 protein, a basic helix-loop-helix transcription factor (predicted molecular weight of 34 kDa). SOX2 is an indispensable factor for regulating embryonic development and in the generation of inducible pluripotent stem (iPS) cells. It is also expressed in neural stem and progenitor cells. Dysregulation of SOX2 is associated with tumorigenesis.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:5000-1:20000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
IHC-Fr 1:100-1:1000
FACS 1:50-1:200
IP 1:100-1:500
Not tested in other applications.

Calculated MW

34 kDa. ( Note )

Positive Control

NT2D1 , hESC , Mouse ESC

Predict Reactivity

Zebrafish, Sheep, Bovine, Cat, Chicken, Pig, Japanese Medaka, Xenopus laevis, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

1XPBS (pH7), 1% BSA, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.15 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human SOX2. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_2038021

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

SRY-box 2 , ANOP3 , MCOPS3

Cellular Localization

Nucleus

Background

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507

GTX101507 IHC-P Image

SOX2 antibody [N1C3] detects SOX2 protein at nucleus in mouse esophagus by immunohistochemical analysis.
Sample: Paraffin-embedded mouse esophagus.
SOX2 antibody [N1C3] (GTX101507) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507

GTX101507 WB Image

Comparison

Whole cell extract (30 μg) was separated by 12% SDS-PAGE, and the membranes were blotted with SOX2 antibody [N1C3] (GTX101507) diluted at 1:1000 and competitor's antibody (sc-17320) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

*The competitor is not affiliated with GeneTex and does not endorse this product.

Anti-SOX2 antibody [N1C3] used in IHC (Frozen sections) (IHC-Fr). GTX101507

GTX101507 IHC-Fr Image

SOX2 antibody [N1C3] detects SOX2 protein at nucleus by immunohistochemical analysis.
Sample: Frozen sectioned E13.5 rat brain.
Green: SOX2 protein stained by SOX2 antibody [N1C3] (GTX101507) diluted at 1:250.
Red: beta Tubulin 3/ TUJ1, a mature neuron marker, stained by beta Tubulin 3/ TUJ1 antibody [GT11710] (GTX631836) diluted at 1:250.
Blue: Fluoroshield with DAPI (GTX30920).
Anti-SOX2 antibody [N1C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX101507

GTX101507 ICC/IF Image

Immunofluorescence analysis of paraformaldehyde-fixed Human ESC, using SOX2(GTX101507) antibody at 1:160 dilution.

Anti-SOX2 antibody [N1C3] used in Flow cytometry (FACS). GTX101507

GTX101507 FACS Image

Flow cytometry on human embryonic stem cells, staining with SOX2 (GTX101507)antibody at 1:100 dilution(purple) or rabbit IgG (black).

Anti-SOX2 antibody [N1C3] used in IHC (Frozen sections) (IHC-Fr). GTX101507

GTX101507 IHC-Fr Image

SOX2 antibody [N1C3] detects SOX2 protein at nucleus by immunohistochemical analysis.
Sample: Frozen sectioned adult mouse retina.
Green: SOX2 protein stained by SOX2 antibody [N1C3] (GTX101507) diluted at 1:250.
Red: Protein kinase C alpha staining.
Blue: Fluoroshield with DAPI (GTX30920).
Anti-SOX2 antibody [N1C3] used in Immunoprecipitation (IP). GTX101507

GTX101507 IP Image

Immunoprecipitation of SOX2 protein from NT2D1 whole cell extracts using 5 μg of SOX2 antibody [N1C3] (GTX101507).
Western blot analysis was performed using SOX2 antibody [N1C3] (GTX101507).
EasyBlot anti-Rabbit IgG (GTX221666-01) was used as a secondary reagent.

Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507

GTX101507 WB Image

SOX2 antibody detects SOX2 protein by Western blot analysis. Whole cell extracts (30 μg) was separated by 12% SDS-PAGE, and the membrane was blotted with SOX2 antibody (GTX101507) at a dilution of 1:2500.

Anti-SOX2 antibody [N1C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX101507

GTX101507 ICC/IF Image

Immunofluorescence analysis of paraformaldehyde-fixed mouse ESC, using SOX2(GTX101507) antibody at 1:80 dilution.

Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507

GTX101507 IHC-P Image

SOX2 antibody [N1C3] detects SOX2 protein at nucleus on rat brain stem by immunohistochemical analysis.
Sample: Paraffin-embedded rat brain stem.
SOX2 antibody [N1C3] (GTX101507) dilution: 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507

GTX101507 IHC-P Image

SOX2 antibody [N1C3] detects SOX2 protein at nucleus in mouse fetal brain by immunohistochemical analysis.
Sample: Paraffin-embedded mouse fetal brain.
Green: SOX2 antibody [N1C3] (GTX101507) diluted at 1:200. The signal was developed using goat anti-rabbit IgG antibody (Dylight488) (GTX213110-04).
Blue: Nuclear staining with Hoechst 33342.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507

GTX101507 IHC-P Image

SOX2 antibody [N1C3] detects SOX2 protein at nucleus on mouse fore brain by immunohistochemical analysis.
Sample: Paraffin-embedded mouse fore brain.
SOX2 antibody [N1C3] (GTX101507) diluted at 1:500.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507

GTX101507 IHC-P Image

SOX2 antibody [N1C3] detects SOX2 protein at nucleus in human cervical carcinoma by immunohistochemical analysis.
Sample: Paraffin-embedded human cervical carcinoma.
SOX2 antibody [N1C3] (GTX101507) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507

GTX101507 WB Image

SOX2 antibody detects SOX2 protein by western blot analysis. Mouse ESC lysate (50 μg) was separated by 10% SDS-PAGE, and the membrane was blotted with SOX2 antibody (GTX101507) at a dilution of 1:2500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-SOX2 antibody [N1C3] used in Immunoprecipitation (IP). GTX101507

GTX101507 IP Image

Immunoprecipitation of SOX2 protein from NT2D1 whole cell extracts using 5 μg of SOX2 antibody [N1C3] (GTX101507) or SOX2 antibody [GT1876] (GTX627404).
Western blot analysis was performed using SOX2 antibody [N1C3] (GTX101507) diluted at 1:500.
EasyBlot anti-Rabbit IgG (GTX221666-01) was used as a secondary reagent.

Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507

GTX101507 WB Image

KO/KD

Non-transfected (–) and transfected (+) NT2D1 whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with SOX2 antibody [N1C3] (GTX101507) diluted at 1:15000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-SOX2 antibody [N1C3] used in IHC (Frozen sections) (IHC-Fr). GTX101507

GTX101507 IHC-Fr Image

SOX2 antibody [N1C3] detects SOX2 protein expression by immunohistochemical analysis.
Sample: Frozen-sectioned adult mouse hippocampus.
Green: SOX2 protein stained by SOX2 antibody [N1C3] (GTX101507) diluted at 1:250.
Blue: Fluoroshield with DAPI (GTX30920).
Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507

GTX101507 WB Image

Whole cell extract (30 μg) was separated by 12% SDS-PAGE, and the membrane was blotted with SOX2 antibody [N1C3] (GTX101507) diluted at 1:10000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507

GTX101507 IHC-P Image

Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using SOX2(GTX101507) antibody at 1:100 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-SOX2 antibody [N1C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX101507

GTX101507 ICC/IF Image

SOX2 antibody [N1C3] detects SOX2 protein at nucleus by immunofluorescent analysis.
Sample: NT2D1 cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: SOX2 stained by SOX2 antibody [N1C3] (GTX101507) diluted at 1:500.
Red: phalloidin, a cytoskeleton marker, diluted at 1:100.
Scale bar= 10 μm.

Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507

GTX101507 IHC-P Image

SOX2 antibody [N1C3] detects SOX2 protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded human esophageal carcinoma.
SOX2 stained by SOX2 antibody [N1C3] (GTX101507) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

REFERENCE

Application Reference

Gupta A et al. Life (Basel) 2021; 11 (12) Activation of the Hippo Pathway in Rana sylvatica: Yapping Stops in Response to Anoxia.
Application : WB
Reactivity : Frog
Ting HC et al. Cells 2021; 10 (10) Coactivation of GSK3β and IGF-1 Attenuates Amyotrophic Lateral Sclerosis Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons.
Application : ICC/IF
Reactivity : Human
Wang SM et al. Cell Death Discov 2021; 7 (1) : 8 CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma.
Application : WB
Reactivity : Human
Carelli S et al. Nanotheranostics 2021; 5 (1) : 8-26 Neural precursors cells expanded in a 3D micro-engineered niche present enhanced therapeutic efficacy in vivo.
Application : WB
Reactivity : Mouse
Yu-Fan Chiu et al. Sci Rep 2020; 10 (1) : 8261 Critical role of SOX2-IGF2 signaling in aggressiveness of bladder cancer.
Application : IHC-P
Reactivity : Rat
Show More +
Submit a Reference

REVIEW

SOX2 antibody [N1C3] Cat No. GTX101507

Rating
( Average 4.8 based on 12 users reviews)
Application
Western Blot(WB)
( Average 4.7 based on 6 users reviews)
Immunocytochemistry/ Immunofluorescence(ICC/IF)
( Average 5 based on 3 users reviews)
IHC (Paraffin sections)(IHC-P)
( Average 5 based on 2 users reviews)
IHC (Frozen sections)(IHC-Fr)
( Average 5 based on 1 users reviews)
Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Neural Plast in 2016. PMID: 28018679
Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal Neural Plast in 2016. PMID: 28018679
Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Dis Model Mech in 2018. PMID: 29208635
Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Ms
Figure Note : The data was peer reviewed and published in the journal J Cancer in 2020. PMID: 32201526
Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : IHC-P
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal Sci Rep in 2020. PMID: 32427884
Anti-SOX2 antibody [N1C3] used in IHC (Paraffin sections) (IHC-P). GTX101507
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : IHC-P
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal Oncotarget in 2020. PMID: 32256979
Anti-SOX2 antibody [N1C3] used in IHC (Frozen sections) (IHC-Fr). GTX101507
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : IHC-Fr
Sample Species : Rat
Figure Note : The data was peer reviewed and published in the journal Evid Based Complement Alternat Med in 2012. PMID: 23320038
Anti-SOX2 antibody [N1C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX101507
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : ICC/IF
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Int J Mol Sci in 2020. PMID: 32316576
Anti-SOX2 antibody [N1C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX101507
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : ICC/IF
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal PLoS One in 2016. PMID: 27802323
Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Stem Cell Res Ther in 2013. PMID: 24423398
Anti-SOX2 antibody [N1C3] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX101507
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : ICC/IF
Sample Species : Ceratotherium simum
Figure Note : The data was peer reviewed and published in the journal Nat Commun in 2018. PMID: 29973581
Anti-SOX2 antibody [N1C3] used in Western Blot (WB). GTX101507
Date : Anonymous submitted on 18-Jul-2016
Score :
Application Tested : WB
Sample Species : Hu
Sample : A549 cells, T24 cells
Amount used : 1* 10^5 cells
Blocking : 5% milk, 25°C, 1Hr
Primary Antibody : 1:1000, 4°C, 16Hr
Lane Description : Lane 1: A549 cells, Lane 2: T24 cells.
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Submit a Review
Application Reference
Gupta A et al. Life (Basel) 2021; 11 (12) Activation of the Hippo Pathway in Rana sylvatica: Yapping Stops in Response to Anoxia.
Application : WB
Reactivity : Frog
Ting HC et al. Cells 2021; 10 (10) Coactivation of GSK3β and IGF-1 Attenuates Amyotrophic Lateral Sclerosis Nerve Fiber Cytopathies in SOD1 Mutant Patient-Derived Motor Neurons.
Application : ICC/IF
Reactivity : Human
Wang SM et al. Cell Death Discov 2021; 7 (1):8 CCAAT/Enhancer-binding protein delta mediates glioma stem-like cell enrichment and ATP-binding cassette transporter ABCA1 activation for temozolomide resistance in glioblastoma.
Application : WB
Reactivity : Human
Carelli S et al. Nanotheranostics 2021; 5 (1):8-26 Neural precursors cells expanded in a 3D micro-engineered niche present enhanced therapeutic efficacy in vivo.
Application : WB
Reactivity : Mouse
Yi-Chieh Yang et al. Int J Mol Sci 2020; 21 (8) Monoamine Oxidase B Expression Correlates with a Poor Prognosis in Colorectal Cancer Patients and Is Significantly Associated with Epithelial-to-Mesenchymal Transition-Related Gene Signatures.
Application : ICC/IF
Reactivity : Human
Erika N Assoun et al. Oncotarget 2020; 11 (12):1075-1084 Characterization of iPS87, a prostate cancer stem cell-like cell line.
Application : IHC-P
Reactivity : Rat
Yu-Fan Chiu et al. Sci Rep 2020; 10 (1):8261 Critical role of SOX2-IGF2 signaling in aggressiveness of bladder cancer.
Application : IHC-P
Reactivity : Rat
Tsai LH et al. Sci Rep 2020; 10 (1):17817 Targeting interleukin-17 receptor B enhances gemcitabine sensitivity through downregulation of mucins in pancreatic cancer.
Application : WB
Reactivity : Human
Chu EP et al. Stem Cell Res 2020; 49:102029 Establishment of three human induced pluripotent stem cell lines from a type 1 diabetic family harboring sequence variants associated with autoimmunity.
Application : ICC/IF
Reactivity : Human
Hsu HS et al. J Biomed Sci 2020; 27 (1):5 Involvement of collagen XVII in pluripotency gene expression and metabolic reprogramming of lung cancer stem cells.
Blanas A et al. Cancers (Basel) 2020; 12 (9) FUT9-Driven Programming of Colon Cancer Cells towards a Stem Cell-Like State.
Application : ICC/IF, FACS
Reactivity : Mouse
Zhang G et al. Cancer Sci 2020; 111 (11):4166-4176 RBPJ contributes to the malignancy of glioblastoma and induction of proneural-mesenchymal transition via IL-6-STAT3 pathway.
Application : WB
Reactivity : Human
Chi HC et al. Oncogene 2020; 39 (37):5933-5949 DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/β-catenin signaling and cancer stem cell traits.
Application : WB
Reactivity : Human
Wang J et al. Front Cell Neurosci 2020; 14:581861 The Effect of IDO on Neural Progenitor Cell Survival Under Oxygen Glucose Deprivation.
Application : ICC/IF
Reactivity : Human
Kerschner JL et al. J Cell Mol Med 2020; A functional genomics approach to investigate the differentiation of iPSCs into lung epithelium at air-liquid interface.
Reactivity : Human
Chiou HC et al. Neoplasia 2020; 22 (7):263-271 Stemness regulation of the adrenal mixed corticomedullary tumorigenesis-a case-control study.
Application : IHC-P
Reactivity : Human
Wang IH et al. Cancers (Basel) 2020; 12 (5) Mevalonate Pathway Enzyme HMGCS1 Contributes to Gastric Cancer Progression.
Application : WB
Reactivity : Human
He X et al. Stem Cell Res Ther 2020; 11 (1):157 Characterisation of extraembryonic endoderm-like cells from mouse embryonic fibroblasts induced using chemicals alone.
Application : ICC/IF
Reactivity : Mouse
Zhao T et al. Stem Cell Reports 2020; 14 (3):493-505 lncRNA 5430416N02Rik Promotes the Proliferation of Mouse Embryonic Stem Cells by Activating Mid1 Expression through 3D Chromatin Architecture.
Application : WB
Reactivity : Mouse
Wang CH et al. Sci Rep 2020; 10 (1):2187 The novel application of cordycepin in maintaining stem cell pluripotency and increasing iPS cell generation efficiency.
Application : WB
Reactivity : Mouse
Li X et al. J Cancer 2020; 11 (9):2560-2571 Function of BMP4 in the Formation of Vasculogenic Mimicry in Hepatocellular Carcinoma.
Application : WB
Reactivity : Human
Chen YL et al. Cancers (Basel) 2019; 12 (1) ERK Activation Modulates Cancer Stemness and Motility of a Novel Mouse Oral Squamous Cell Carcinoma Cell Line.
Yang SC et al. FASEB J 2019; 33 (9):10577-10592 Down-regulation of ATF1 leads to early neuroectoderm differentiation of human embryonic stem cells by increasing the expression level of SOX2.
Fletcher PA et al. Front Endocrinol (Lausanne) 2019; 10:623 Cell Type- and Sex-Dependent Transcriptome Profiles of Rat Anterior Pituitary Cells.
Application : ICC/IF
Reactivity : Rat
Chang WF et al. Int J Mol Sci 2019; 20 (5) Compromised Chondrocyte Differentiation Capacity in TERC Knockout Mouse Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer.
Chien CH et al. J Biomed Sci 2019; 26 (1):77 Enrichment of superoxide dismutase 2 in glioblastoma confers to acquisition of temozolomide resistance that is associated with tumor-initiating cell subsets.
Application : WB
Reactivity : Human
Bayat Mokhtari R et al. BMC Cancer 2019; 19 (1):864 Human bronchial carcinoid tumor initiating cells are targeted by the combination of acetazolamide and sulforaphane.
Application : ICC/IF
Reactivity : Human
Chen YH et al. Sci Rep 2019; 9 (1):9919 Mitochondrial Akt Signaling Modulated Reprogramming of Somatic Cells.
Application : ICC/IF
Reactivity : Human
Wang L et al. Toxicol Appl Pharmacol 2019; 376:9-16 Tanshinone prevents alveolar bone loss in ovariectomized osteoporosis rats by up-regulating phosphoglycerate dehydrogenase.
Application : WB
Reactivity : Rat
Yang Y et al. Neurochem Res 2019; 44 (4):811-828 MiR-124 Enriched Exosomes Promoted the M2 Polarization of Microglia and Enhanced Hippocampus Neurogenesis After Traumatic Brain Injury by Inhibiting TLR4 Pathway.
Application : IHC-P
Reactivity : Rat
Mansel C et al. Neurotoxicol Teratol 2019; 72:58-70 Lead exposure reduces survival, neuronal determination, and differentiation of P19 stem cells.
Application : ICC/IF
Reactivity : Mouse
Zhong PQ et al. Cell Signal 2019; 53:390-399 ACTL6A interacts with p53 in acute promyelocytic leukemia cell lines to affect differentiation via the Sox2/Notch1 signaling pathway.
Application : WB
Reactivity : Human
Hildebrandt TB et al. Nat Commun 2018; 9 (1):2589 Embryos and embryonic stem cells from the white rhinoceros.
Application : ICC/IF
Reactivity : Mouse
Fawal MA et al. Cell Rep 2018; 23 (10):2864-2873.e7 Cross Talk between One-Carbon Metabolism, Eph Signaling, and Histone Methylation Promotes Neural Stem Cell Differentiation.
Application : ICC/IF
Reactivity : Mouse
Shen Z et al. Elife 2017; 6 Enforcement of developmental lineage specificity by transcription factor Oct1.
Yoshimura A et al. Dis Model Mech 2017; (Epub) The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking neural stem cell-derived extracellular vesicles.
Application : IHC-Fr
Ko CY et al. Mol Neurobiol 2017; (Epub) MDM2 Degrades Deacetylated Nucleolin Through Ubiquitination to Promote Glioma Stem-Like Cell Enrichment for Chemotherapeutic Resistance.
Application : WB
Reactivity : Human
Lin HC et al. J Agric Food Chem 2017; 65 (1):51-59 Antroquinonol, a Ubiquinone Derivative from the Mushroom Antrodia camphorata, Inhibits Colon Cancer Stem Cell-like Properties: Insights into the Molecular Mechanism and Inhibitory Targets.
Application : WB
Reactivity : Human
Gong W et al. Am J Cancer Res 2017; 7 (3):503-517 Nodal signaling activates the Smad2/3 pathway to regulate stem cell-like properties in breast cancer cells.
Application : WB
Reactivity : Human
Chen MW et al. Cancer Res 2017; The STAT3-miRNA-92-Wnt signaling pathway regulates spheroid formation and malignant progression in ovarian cancer.
Gazarian KG et al. PLoS One 2017; 12 (1):e0170321 Human Deciduous Teeth Stem Cells (SHED) Display Neural Crest Signature Characters.
Application : ICC/IF
Reactivity : Human
Ye Y et al. Neural Plast 2016; 2016:8072156 Activation of Sphingosine 1-Phosphate Receptor 1 Enhances Hippocampus Neurogenesis in a Rat Model of Traumatic Brain Injury: An Involvement of MEK/Erk Signaling Pathway.
Hsu CC et al. J Biomed Sci 2016; 23 (1):81 Suberoylanilide hydroxamic acid represses glioma stem-like cells.
Ye Y et al. Neural Plasticity 2016; (Epub) Activation of sphingosine 1-phosphate receptor 1 enhances hippocampus neurogenesis in a rat model of traumatic brain injury: an involvement of MEK/Erk signaling pathway.
Application : IHC-P
Reactivity : Rat
Chang WF et al. PLoS One 2016; 11 (11):e0165715 Derivation of Patient Specific Pluripotent Stem Cells Using Clinically Discarded Cumulus Cells.
Application : ICC/IF
Reactivity : Human
Chen MJ et al. Sci Rep 2016; 6:34933 PAK1 confers chemoresistance and poor outcome in non-small cell lung cancer via β-catenin-mediated stemness.
Application : WB
Reactivity : Human
Petrova A et al. Stem Cells Dev 2016; 25 (18):1366-75 Induced Pluripotent Stem Cell Differentiation and Three-Dimensional Tissue Formation Attenuate Clonal Epigenetic Differences in Trichohyalin.
Application : ICC/IF
Reactivity : Human
Zhang W et al. Sci Rep 2016; 6:26804 Cops2 promotes pluripotency maintenance by Stabilizing Nanog Protein and Repressing Transcription.
Application : WB
Reactivity : Human
Chen CH et al. Anim Biotechnol 2016; 27 (3):157-65 Germline Competent Pluripotent Mouse Stem Cells Generated by Plasmid Vectors.
Application : ICC/IF
Reactivity : Human
Zhao T et al. PLoS One 2015; 10 (9):e0138168 Roles of Klf5 Acetylation in the Self-Renewal and the Differentiation of Mouse Embryonic Stem Cells.
Application : WB
Reactivity : Mouse
Mineda K et al. Stem Cells Transl Med 2015; 4 (12):1511-22 Therapeutic Potential of Human Adipose-Derived Stem/Stromal Cell Microspheroids Prepared by Three-Dimensional Culture in Non-Cross-Linked Hyaluronic Acid Gel.
Application : IHC-Fr
Reactivity : Human
Chen H et al. Proc Natl Acad Sci U S A 2015; 112 (44):E5936-43 Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells.
Application : WB
Reactivity : Mouse
Wang AM et al. Oncotarget 2014; 5 (13):5002-16 Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis.
Application : WB
Reactivity : Human
Hung YH et al. Mol Neurobiol 2014; Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons.
Application : WB
Reactivity : Rat
Emhemmed F et al. Biochem Pharmacol 2014; Selective anticancer effects of a synthetic flavagline on human Oct4-expressing cancer stem-like cells via a p38 MAPK-dependent caspase-3-dependent pathway.
Application : WB
Reactivity : Human
Misuno K et al. Stem Cell Res Ther 2013; 4 (6):156 Quantitative proteomic analysis of sphere-forming stem-like oral cancer cells.
Application : WB
Reactivity : Human
Hsue-Yin Hsu et al. Evid Based Complement Alternat Med 2012; 2012 (0):819632 Antimigratory Effects of the Methanol Extract from Momordica charantia on Human Lung Adenocarcinoma CL1 Cells.
Application : IHC-Fr
Reactivity : Rat
SDS
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