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SP110 antibody

Anti-SP110 antibody used in IHC (Paraffin sections) (IHC-P). GTX85042
Anti-SP110 antibody used in IHC (Paraffin sections) (IHC-P). GTX85042
Anti-SP110 antibody used in Western Blot (WB). GTX85042

Cat. No. GTX85042

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all SP110 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5 - 2 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

78 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , HeLa Cell Lysate

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

SP110 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human SP110.The immunogen is located within amino acids 470 - 520 of SP110.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

SP110 nuclear body protein , IFI41 , IFI75 , IPR1 , VODI

Cellular Localization

Nucleus

Background

Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.

Database

Research Area

DATA IMAGES

Anti-SP110 antibody used in IHC (Paraffin sections) (IHC-P). GTX85042

GTX85042 IHC-P Image

IHC-P analysis of human brain tissue using GTX85042 SP110 antibody.
Working concentration : 2.5 μg/ml

Anti-SP110 antibody used in IHC (Paraffin sections) (IHC-P). GTX85042

GTX85042 IHC-P Image

IHC-P analysis of human brain tissue using GTX85042 SP110 antibody.
Working concentration : 50 μg/ml

Anti-SP110 antibody used in Western Blot (WB). GTX85042

GTX85042 WB Image

WB analysis of HeLa cell lysate using GTX85042 SP110 antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399