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SREBP1 antibody

Anti-SREBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31579
Anti-SREBP1 antibody used in Western Blot (WB). GTX31579
Anti-SREBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31579

Cat No. GTX31579

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P, ELISA

Reactivity

Human, Mouse
Package
100 μg ($339)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 - 2 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

122 kDa. ( Note )

Positive Control

Daudi Cell Lysate(GTX23951) , Human Spleen Tissue Slide

Specificity/Sensitivity

At least three isoforms of SREBF1 are known to exist. SREBF1 antibody is predicted not to cross-react with SREBF2.

PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

SREBP1 antibody was raised against a 17 amino acid peptide near the center of human SREBP1.The immunogen is located within amino acids 450 - 500 of SREBP1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

sterol regulatory element binding transcription factor 1 , SREBP1 , bHLHd1

Cellular Localization

Endoplasmic reticulum membrane,Golgi apparatus membrane

Background

This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-SREBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31579

GTX31579 IHC-P Image

IHC-P analysis of human spleen tissue using GTX31579 SREBP1 antibody.
Working concentration : 20 μg/ml

Anti-SREBP1 antibody used in Western Blot (WB). GTX31579

GTX31579 WB Image

WB analysis of Daudi cell lysate using GTX31579 SREBP1 antibody.
Working concentration : 1 μg/ml

Anti-SREBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX31579

GTX31579 IHC-P Image

IHC-P analysis of human spleen tissue using GTX31579 SREBP1 antibody.
Working concentration : 5 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 339