APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:1000 |
| 1:50-1:100 |
| 1:10-1:50 |
Not tested in other applications.
Calculated MW
Predict Reactivity
Mouse, Rat, Zebrafish(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
KLH conjugated synthetic peptide between 81-108 amino acids from the N-terminal region of human ABI1.
Purification
Protein A purified, followed by peptide affinity purification.
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
abl interactor 1 , ABI-1 , ABLBP4 , E3B1 , NAP1BP , SSH3BP , SSH3BP1
Cellular Localization
Cytoplasm,Nucleus,Cytoplasm, cytoskeleton
Background
This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interactions with Abelson tyrosine kinases. The encoded protein plays a role in macropinocytosis as a component of the WAVE2 complex, and also forms a complex with EPS8 and SOS1 that mediates signal transduction from Ras to Rac. This gene may play a role in the progression of several malignancies including melanoma, colon cancer and breast cancer, and a t(10;11) chromosomal translocation involving this gene and the MLL gene has been associated with acute myeloid leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 14. [provided by RefSeq, Sep 2011]
Database
Research Area
DATA IMAGES
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GTX81190 WB Image
WB analysis of MCF-7, CEM, Jurkat cell lysate (35ug/lane) using GTX81190 SSH3BP1 antibody, N-term.
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GTX81190 IHC-P Image
IHC-P analysis of human brain tissue using GTX81190 SSH3BP1 antibody, N-term.
Green : SSH3BP1
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GTX81190 FACS Image
FACS analysis of SK-Br-3 cells using GTX81190 SSH3BP1 antibody, N-term.
Top histogram : negative control
Bottom histogram : SK-Br-3 cells
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GTX81190 IHC-P Image
IHC-P analysis of human brain tissue using GTX81190 SSH3BP1 antibody, N-term.
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REFERENCE
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REVIEW
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