PBS with 0.1% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Synthetic peptide (Human) (C terminal).
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Signal Transducer And Activator Of Transcription 2,Imd44,Isgf-3,P113,Stat113,Stat2
Abnormal signaling of the JAK-STAT pathway has been implicated in hematopoietic disorders including SCID and leukemia (4), and programming gene expression in biological events such as embryonic development, apoptosis, organogenesis, innate immunity, adaptive immunity and cell growth regulation (3). STAT1 knockout mice are defective in interferon-mediated functions. STAT4 and STAT6 knockout mice show defective responses to IL-12 and IL-4, respectively. Analyses of STAT5a and STAT5b knockout mice reveal important roles in prolactin-mediated mammary gland development and growth hormone-mediated induction of sexual dimorphism, respectively. Conditional knockout study of STAT3 demonstrates its critical roles in cytokine-mediated functions in several tissues, including T cells, macrophages, skin, and mammary gland (5). STAT1/STAT2 form a heterodimer which, in association with a DNA-binding adapter protein, p48/IFN regulatory factor-9 (IRF-9), is part of the ISGF3 transcription factor complex (6).