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STAT2 (phospho Tyr690) antibody

Orthogonal
Anti-STAT2 (phospho Tyr690) antibody used in Western Blot (WB). GTX50721
Anti-STAT2 (phospho Tyr690) antibody used in Western Blot (WB). GTX50721

Cat. No. GTX50721

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human
Package
100 μl ($399)
See all STAT2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:1000
Not tested in other applications.

Calculated MW

98 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide sequence around phosphorylation site of tyrosine 690 (R-K-Y(p)-L-K)derived from human STAT2.

Purification

Purified by antigen-affinity chromatography. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

Conjugation

Unconjugated

RRID

AB_11170713

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

signal transducer and activator of transcription 2 , IMD44 , ISGF-3 , P113 , STAT113

Cellular Localization

Cytoplasm,Nucleus

Background

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Database

Research Area

DATA IMAGES

Anti-STAT2 (phospho Tyr690) antibody used in Western Blot (WB). GTX50721

GTX50721 WB Image

WB analysis of extracts from HeLa cells untreated or treated with IFN-a using GTX50721 STAT2 (phospho Tyr690) antibody.

Anti-STAT2 (phospho Tyr690) antibody used in Western Blot (WB). GTX50721

GTX50721 WB Image

Orthogonal

The data was published in the journal Front Cell Infect Microbiol in 2018. PMID: 30186771

REFERENCE

Application Reference

Yoshikawa R et al. J Biol Chem 2023; 299 (6) : 104819 The NSs protein of severe fever with thrombocytopenia syndrome virus differentially inhibits the type 1 interferon response among animal species.
Wei KC et al. Front Cell Infect Microbiol 2018; 8 : 268 Dengue Virus Infects Primary Human Hair Follicle Dermal Papilla Cells.
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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399