GeneTex

  • Country / Location Selection

United States (US)

STAT5 antibody

Anti-STAT5 antibody used in IHC (Paraffin sections) (IHC-P). GTX37534

Cat. No. GTX37534

Reference 4

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
50 μg ($399)
See all STAT5 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
IHC-P 1:400-800
Not tested in other applications.

Calculated MW

91 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.01M TBS, 0.5% BSA, 25% Glycerol

Preservative

0.015% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

KLH conjugated synthetic peptide derived between 71-150 amino acids of human STAT5

Purification

Protein A purified

Conjugation

Unconjugated

RRID

AB_11165738

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

signal transducer and activator of transcription 5A , MGF , STAT5

Cellular Localization

Cytoplasm,Nucleus

Background

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Database

Research Area

DATA IMAGES

Anti-STAT5 antibody used in IHC (Paraffin sections) (IHC-P). GTX37534

GTX37534 IHC-P Image

IHC-P analysis of human lung carcinoma tissue using GTX37534 STAT5 antibody.
Fixation : 4% PFA
Antigen retireval : boiling with citrate buffer
Dilution : 1:200

REFERENCE

Application Reference

Huang SH et al. Int J Mol Sci 2022; 23 (3) Alpha-Lipoic Acid Inhibits Spontaneous Diabetes and Autoimmune Recurrence in Non-Obese Diabetic Mice by Enhancing Differentiation of Regulatory T Cells and Showed Potential for Use in Cell Therapies for the Treatment of Type 1 Diabetes.
Application : WB
Peng HY et al. Mol Oncol 2016; pii: S1574-7891 (16) : 30001-1 IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma.
Application : WB
Reactivity : Human
Lu JW et al. Cancer Lett 2016; (Epub) * is selectively cytotoxic in acute myeloid leukemia cells with flt3-internal tandem duplication (flt3-itd).
Application : WB
Reactivity : Human
Vazquez-Mellado MJ et al. Life Sci 2015; 137 (Epub) : 142-9 erythropoietin protects neuroblastoma cells against * and * by activating erk and akt pathways but has no effect in kidney cells.
Application : WB
Reactivity : Human
Submit a Reference

REVIEW

There are currently no reviews for STAT5 antibody (GTX37534). Be the first to share your experience with this product.
Submit a Review
SDS
Glycerol.pdf
Proclin.pdf
Package List Price ($)
$ 399