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STAT5A (phospho Ser780) antibody

Anti-STAT5A (phospho Ser780) antibody used in IHC (Paraffin sections) (IHC-P). GTX78937
Anti-STAT5A (phospho Ser780) antibody used in Western Blot (WB). GTX78937

Cat. No. GTX78937

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human
Package
100 μg ($399)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:1000
IHC-P 1:50 - 1:100
Not tested in other applications.

Calculated MW

91 kDa. ( Note )

Predict Reactivity

Mouse, Rat(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS (without Mg²⁺ and Ca²⁺) pH7.4, 150mM NaCl, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized phosphopeptide derived from human STAT5A around the phosphorylation site of serine 780 (R-L-Sp-P-P).

Purification

Purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns.
From serum

Conjugation

Unconjugated

RRID

AB_11173522

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

MGF,STAT5,STAT5A,signal transducer and activator of transcription 5A

Cellular Localization

Cytoplasm,Nucleus

Background

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Database

Research Area

DATA IMAGES

Anti-STAT5A (phospho Ser780) antibody used in IHC (Paraffin sections) (IHC-P). GTX78937

GTX78937 IHC-P Image

IHC-P analysis of human breast carcinoma tissue using GTX78937 STAT5A (phospho Ser780) antibody.

Anti-STAT5A (phospho Ser780) antibody used in Western Blot (WB). GTX78937

GTX78937 WB Image

WB analysis of HeLa cell lysate using GTX78937 STAT5A (phospho Ser780) antibody.

REFERENCE

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REVIEW

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Package List Price ($)
$ 399