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STAT6 (phospho Tyr641) antibody

Anti-STAT6 (phospho Tyr641) antibody used in IHC (Paraffin sections) (IHC-P). GTX32357
Anti-STAT6 (phospho Tyr641) antibody used in Western Blot (WB). GTX32357

Cat No. GTX32357

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, IHC-P

Reactivity

Human
Package
100 μl ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:500 - 1:1000
IHC-P 1:100 - 1:200
Not tested in other applications.

Calculated MW

94 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.42% Potassium phosphate, 0.87% Sodium chloride pH 7.3, 30% glycerol, 0.01% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20º C or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

KLH-conjugated synthetic peptide encompassing a sequence within the center region of STAT6. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

signal transducer and activator of transcription 6 , D12S1644 , IL-4-STAT , STAT6B , STAT6C

Cellular Localization

Cytoplasm,Nucleus

Background

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Database

Research Area

DATA IMAGES

Anti-STAT6 (phospho Tyr641) antibody used in IHC (Paraffin sections) (IHC-P). GTX32357

GTX32357 IHC-P Image

IHC-P analysis of formalin fixed human breast cancer tissue section using GTX32357 STAT6 (phospho Tyr641) antibody.
Antigen retrieval : Heat mediated antigen retrieval with sodium citrate buffer (pH 6.0)

Anti-STAT6 (phospho Tyr641) antibody used in Western Blot (WB). GTX32357

GTX32357 WB Image

WB analysis of IL4-treated HepG2 (A), IL4-treated HeLa (B) whole cell lysates using GTX32357 STAT6 (phospho Tyr641) antibody.

REFERENCE

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REVIEW

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Package List Price ($)
$ 319