GeneTex
United States (US)

STEAP3 antibody

STEA3-antibody-GTX87995-WB-1_18121411_748.jpg
STEA3-antibody-GTX87995-ICC_IF-1_18121411_733.jpg

Cat No. GTX87995

Host Rabbit
Clonality Polyclonal
Application WB, ICC/IF, ELISA
Reactivity Human, Mouse, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
ICC/IF Assay dependent
ELISA Assay dependent
Not tested in other applications.

Calculated MW

54 kDa. ( Note )

Specificity/Sensitivity

STEA3 Antibody detects endogenous levels of total STEA3 protein.
PROPERTIES

Form

Liquid

Buffer

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Antigen Species

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human STEAP3.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

hTSAP6, EC1.16.1., Six-transmembrane epithelial antigen of prostate 3, Dudulin2, pHyde, STEA3, Tumor suppressoractivated pathway protein 6, Sixtransmembrane epithelial antigen of prostate3, EC 1.16.1.-, Tumor suppressor-activated pathway protein 6, Sixtransmembrane epithelial antigen of prostate 3, Tumor suppressoractivated pathway protein6, hpHyde, EC 1.16.1.

Cellular Localization

Localizes to vesicular-like structures at the plasma membrane and around the nucleus.

Background

Endosomal ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Participates in erythroid iron homeostasis by reducing Fe(3+) to Fe(2+). Can also reduce of Cu(2+) to Cu(1+), suggesting that it participates in copper homeostasis. Uses NAD(+) as acceptor (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression. Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP.
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Database

Research Area

DATA IMAGES
STEA3-antibody-GTX87995-WB-1_18121411_748.jpg

GTX87995 WB Image

Western blot analysis of extracts from COLO205 cells, using STEA3 Antibody. The lane on the right is treated with the synthesized peptide.

STEA3-antibody-GTX87995-ICC_IF-1_18121411_733.jpg

GTX87995 ICC/IF Image

Immunofluorescence analysis of HeLa cells, using STEA3 Antibody. The picture on the right is treated with the synthesized peptide.