PRODUCT
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:100-1:200 |
|
Note :
IHC-P
Manual staining : Heat-induced antigen retrieval for 5 minutes in an autoclave at 121ºC in pH 7.8 Tris-EDTA-based Target Retrieval Solution buffer.
|
Not tested in other applications.
Calculated MW
Positive Control
Adrenal gland: Endothelial cells and macrophages should show a moderate to strong STING positivity.
Negative Control
Adrenal gland: Adrenocortical and medullary cells should not show STING staining (Note: in case of tissue damage aberrant STING staining may occur).
PROPERTIES
Form
Liquid
Buffer
PBS, 0.05% BSA (Please contact us for PBS only format)
Preservative
0.05% sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant fragment (around aa190-290) of human TMEM173 protein
Purification
Protein A/G purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
transmembrane protein 173 , ERIS , MITA , MPYS , NET23 , SAVI , STING , STING-beta , hMITA , hSTING
Cellular Localization
Endoplasmic reticulum membrane , Mitochondrion outer membrane , Cell membrane , Cytoplasm, perinuclear region , Cytoplasm
Background
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Database
Research Area
DATA IMAGES
![Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484](/templates/default/js/lightbox/images/loading.gif "Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484")
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GTX04484 IHC-P Image
IHC-P analysis of human adrenal gland tissue using GTX04484 STING antibody [MSVA-515M] HistoMAX™.
STING staining of endothelial cells and of macrophages STING immunohistochemistry.
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GTX04484 IHC-P Image
IHC-P analysis of human mucosa from appendix tissue using GTX04484 STING antibody [MSVA-515M] HistoMAX™.
STING staining of inflammatory cells predominates in the interfollicular zone STING immunohistochemistry.
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GTX04484 IHC-P Image
IHC-P analysis of human pancreatic ductal adenocarcinoma (PDAC) tissue using GTX04484 STING antibody [MSVA-515M] HistoMAX™.
Ductal adenocarcinoma with strong STING positivity of all tumor cells.
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REFERENCE
There are currently no references for STING antibody [MSVA-515M] HistoMAX™ (GTX04484). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for STING antibody [MSVA-515M] HistoMAX™ (GTX04484). Be the first to share your experience with this product.
![Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484](/upload/website/prouct_img/small/GTX04484/GTX04484_20230728_IHC-P_243_23072722_839.webp "Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484")
![Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484](/upload/website/prouct_img/small/GTX04484/GTX04484_20230728_IHC-P_373_23072723_273.webp "Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484")
![Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484](/upload/website/prouct_img/small/GTX04484/GTX04484_20230728_IHC-P_113_23072722_838.webp "Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484")
![Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484](/upload/website/prouct_img/normal/GTX04484/GTX04484_20230728_IHC-P_243_23072722_839.webp "Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484")
![Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484](/upload/website/prouct_img/normal/GTX04484/GTX04484_20230728_IHC-P_373_23072723_273.webp "Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484")
![Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484](/upload/website/prouct_img/normal/GTX04484/GTX04484_20230728_IHC-P_113_23072722_838.webp "Anti-STING antibody [MSVA-515M] HistoMAX™ used in IHC (Paraffin sections) (IHC-P). GTX04484")