APPLICATION
Application Note
Recommended Starting Dilutions:
For WB: Use at 1:1000
For ICC/IF: Use at 1:500
Optimal dilutions should be determined experimentally by the researcher.
Calculated MW
Product Note
Mouse SUN2
PROPERTIES
Form
Liquid
Buffer
Serum
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Mouse
Immunogen
Mouse SUN2 residues 1-18
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
Sad1 and UNC84 domain containing 2 , UNC84B
Cellular Localization
Nucleus inner membrane , Endosome membrane
Background
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
Database
Research Area
REFERENCE
There are currently no references for SUN2 antibody (GTX80312). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for SUN2 antibody (GTX80312). Be the first to share your experience with this product.