GeneTex
United States (US)

SUR1 antibody, C-term

GTX88616_2190_WB_18122102_729.jpg

Cat No. GTX88616

Host Goat
Clonality Polyclonal
Isotype IgG
Application WB
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5-1.5μg/ml
Not tested in other applications.

Calculated MW

177 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX88616-PEP).

Predict Reactivity

Mouse, Rat, Dog(>80% identity)
PROPERTIES

Form

Liquid

Buffer

Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.

Concentration

0.50mg/ml

Antigen Species

Human

Immunogen

Peptide with sequence C-EFDKPEKLLSRKD, from the C Terminus of the protein sequence according to NP_000343.2.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

TNDM2 Antibody , PHHI Antibody , MRP8 Antibody , HHF1 Antibody , ABCC8 Antibody , HI Antibody , SUR Antibody , SUR1DELTA2 Antibody , ABC36 Antibody , HRINS Antibody

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described. [provided by RefSeq, Jul 2008]
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Database

Research Area

DATA IMAGES
GTX88616_2190_WB_18122102_729.jpg

GTX88616 WB Image

WB analysis of human cerebellum lysate using GTX88616 SUR1 antibody, C-term.
Dilution : 0.5µg/ml
Loading : 35µg protein in RIPA buffer