APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:1000-1:3000 |
| 1:100-1:500 |
Not tested in other applications.
Calculated MW
Predict Reactivity
Mouse, Rat, Rabbit, Sheep, Bovine, Dog, Monkey, Horse(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS, 150mM NaCl, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
A synthesized peptide derived from human ABCC8(Accession Q09428), corresponding to amino acid residues V1539-K1581.
Purification
Purified by antigen-affinity chromatography
From serum
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
ABC36,ABCC8,ATP binding cassette subfamily C member 8,HHF1,HI,HRINS,MRP8,PHHI,SUR,SUR1,SUR1delta2,TNDM2
Cellular Localization
Membrane
Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Database
Research Area
DATA IMAGES
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GTX04854 WB Image
WB analysis of HepG2 whole cell lysate using GTX04854 SUR1 antibody. The lane on the left was treated with blocking peptide.
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GTX04854 ICC/IF Image
ICC/IF analysis of PFA-fixed HeLa cells using GTX04854 SUR1 antibody.
Red : Primary antibody
Green : Beta tubulin
Blue : DAPI
Permeabilization : 0.1% Triton X-100
Dilution : 1:200
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GTX04854 WB Image
WB analysis of HepG2 whole cell lysate using GTX04854 SUR1 antibody. The lane on the left was treated with blocking peptide.
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GTX04854 ICC/IF Image
ICC/IF analysis of PFA-fixed HeLa cells using GTX04854 SUR1 antibody.
Red : Primary antibody
Green : Beta tubulin
Blue : DAPI
Permeabilization : 0.1% Triton X-100
Dilution : 1:200
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REFERENCE
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REVIEW
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