GeneTex

  • Country / Location Selection

United States (US)

Securin antibody

Anti-Securin antibody used in IHC (Paraffin sections) (IHC-P). GTX32862
Anti-Securin antibody used in Western Blot (WB). GTX32862
Anti-Securin antibody used in IHC (Paraffin sections) (IHC-P). GTX32862
Anti-Securin antibody used in IHC (Paraffin sections) (IHC-P). GTX32862

Cat. No. GTX32862

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse, Rat
Package
100 μl ($399)
See all Securin products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500 - 1:2000
IHC-P 1:100 - 1:200
Not tested in other applications.

Calculated MW

22 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 50% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-202 of human PTTG1 (NP_001269311.1).

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

pituitary tumor-transforming 1 , EAP1 , HPTTG , PTTG , TUTR1

Cellular Localization

Cytoplasm,Nucleus

Background

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]

Database

Research Area

DATA IMAGES

Anti-Securin antibody used in IHC (Paraffin sections) (IHC-P). GTX32862

GTX32862 IHC-P Image

IHC-P analysis of human stomach tissue using GTX32862 Securin antibody.
Dilution : 1:100

Anti-Securin antibody used in Western Blot (WB). GTX32862

GTX32862 WB Image

WB analysis of various sample lysates using GTX32862 Securin antibody.
Dilution : 1:1000
Loading : 25μg per lane

Anti-Securin antibody used in IHC (Paraffin sections) (IHC-P). GTX32862

GTX32862 IHC-P Image

IHC-P analysis of human lung cancer tissue using GTX32862 Securin antibody.
Dilution : 1:100

Anti-Securin antibody used in IHC (Paraffin sections) (IHC-P). GTX32862

GTX32862 IHC-P Image

IHC-P analysis of human liver tissue using GTX32862 Securin antibody.
Dilution : 1:100

REFERENCE

There are currently no references for Securin antibody (GTX32862). Be the first to share your publications with this product.
Submit a Reference

REVIEW

There are currently no reviews for Securin antibody (GTX32862). Be the first to share your experience with this product.
Submit a Review
SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399