GeneTex
United States (US)

Serotonin Transporter antibody, Internal

GTX31103_1607_WB_18121410_299.jpg

Cat No. GTX31103

Host Goat
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF
Reactivity Human, Rat
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1-3μg/ml
ICC/IF Assay dependent
Not tested in other applications.

Calculated MW

70 kDa. ( Note )

Positive Control

The peptide used to generate this antibody is available for purchase (GTX31103-PEP).

Predict Reactivity

Mouse(>80% identity)
PROPERTIES

Form

Liquid

Buffer

Tris saline pH7.3, 0.02% sodium azide, 0.5% BSA.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.50 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide with sequence C-LHQGERETWGK, from the internal region of the protein sequence according to NP_001036.1.

Purification

Purified by ammonium sulphate precipitation followed by antigen affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Solute Carrier Family 6 Member 4,5-Htt,5-Httlpr,5Htt,Htt,Ocd1,Sert,Sert1,Hsert,Slc6A4

Cellular Localization

Translocates from intracellular locations to the plasma membrane. Density of transporter molecules on the plasma membrane is itself regulated by serotonin.

Background

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX31103_1607_WB_18121410_299.jpg

GTX31103 WB Image

WB analysis of human colon lysate using GTX31103 Serotonin Transporter antibody, Internal.
Dilution : 2µg/ml
Loading : 35µg protein in RIPA buffer

Package List Price ($)
$ 329