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Sprouty 2 antibody

Anti-Sprouty 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX33687
Anti-Sprouty 2 antibody used in Western Blot (WB). GTX33687

Cat No. GTX33687

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Human
Package
100 μl ($339)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

35 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 - 1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The immunogen is a synthetic peptide directed towards the N terminal region of human SPRY2

Purification

Affinity Purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

sprouty RTK signaling antagonist 2 , IGAN3 , hSPRY2

Cellular Localization

Cytoplasm, cytoskeleton

Background

This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

Database

DATA IMAGES
Anti-Sprouty 2 antibody used in IHC (Paraffin sections) (IHC-P). GTX33687

GTX33687 IHC-P Image

Sprouty 2 antibody Formalin Fixed Paraffin Embedded Tissue: Human heart Tissue, Observed Staining: Cytoplasmic in vasculature, Primary Antibody Concentration: 1:100, Other Working Concentrations: 1:600, Secondary Antibody: Donkey anti-Rabbit-Cy3, Secondary Antibody Concentration: 1:200 and Magnification: 20X

Anti-Sprouty 2 antibody used in Western Blot (WB). GTX33687

GTX33687 WB Image

WB Suggested Sprouty 2 antibody Titration: 0.2-1 ug/ml Positive Control: HepG2 cell lysate

REFERENCE
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Package List Price ($)
$ 339