PBS with 0.1% sodium azide
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Synthetic peptide: SNKSKPKDASQRRRSL (Human) conjugated to KLH (N terminal). This Ab recognises both the phosphorylated and non phosphorylated forms.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Src Proto-Oncogene, Non-Receptor Tyrosine Kinase,Asv,Src1,Thc6,C-Src,P60-Src,Src
The Src gene family is represented by at least eight different protein tyrosine kinases belonging to the non-receptor tyrosine kinases (1,2). These protein tyrosine kinases are important regulators of many cellular processes, including cytoskeletal organization, cell-cell contact, DNA synthesis, and cellular proliferation (1-3). Members of this group of proteins include c-Src, c-Yes, Fyn, Lck, Lyn, Hck, Blk and c-Fgr. The proto-oncogene c-Src is the prototype member of this gene family and is expressed in a broad range of tissues and cells (4,5). Elevated c-Src tyrosine kinase activity has been found in many types of human cancers, most notably in breast carcinomas (6,7). The activity of c-Src in these human cancers has been attributed to increases c-Src expression, elevated c-Src specific activity and activating mutations in c-Src (6,7).