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Substance P antibody [NC1/34]

Cat. No. GTX38990

Reference 4

Host

 Rat

Clonality

 Monoclonal

Clone Name

 NC1/34

Isotype

 IgG2a

Application

 ICC/IF, IHC-P, IHC-Fr

Reactivity

 Human, Mouse, Rat, Zebrafish, Rabbit, Sheep, Bovine, Chicken, Guinea pig, Pig, Bichir, Bullfrog, Calanus sp., Camel, Chinchilla, Cockroach, Cowbird, Crayfish, Homarus sp., Lamprey, Mudpuppy, Panilurus sp., pigeon, Spadefoot toad
Package
100 μl ($519)
See all Substance P products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ICC/IF Assay dependent
IHC-P 1/100-1/200
IHC-Fr 1/100-1/200
Not tested in other applications.

Calculated MW

15 kDa. ( Note )

Product Note

This antibody recognizes the COOH terminal end of substance P.

Predict Reactivity

Amphibians(>80% identity)

PROPERTIES

Form

Liquid

Buffer

Tissue culture supernatant

Preservative

0.05% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Immunogen

Substance P conjugated to Bovine Serum Albumin.

Purification

Tissue Culture Supernatant

Conjugation

Unconjugated

RRID

AB_11175924

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tachykinin precursor 1 , Hs.2563 , NK2 , NKNA , NPK , TAC2

Cellular Localization

Secreted

Background

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Substance P is an antimicrobial peptide with antibacterial and antifungal properties. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Database

Research Area

REFERENCE

Application Reference

Giannotti A et al. Int J Mol Sci 2024; 25 (2) Swine Pudendal Nerve as a Model for Neuromodulation Studies to Restore Lower Urinary Tract Dysfunction.
He FL et al. J Neurosurg 2020; : 1-11 Covering the proximal nerve stump with chondroitin sulfate proteoglycans prevents traumatic painful neuroma formation by blocking axon regeneration after neurotomy in Sprague Dawley rats.
Sone PP et al. J Endod 2020; 46 (7) : 943-949 Neural Regeneration/Remodeling in Engineered Coronal Pulp Tissue in the Rat Molar.
Tan WQ et al. Br J Pharmacol 2018; (Epub) Angiotensin-converting enzyme inhibitor works as a scar formation inhibitor by downregulating Smad and TAK1 pathways in mice.
Application : IHC-P
Reactivity : Mouse
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Package List Price ($)
$ 519