GeneTex
United States (US)

Survivin antibody

Survivin-antibody_IHC-P_GTX28113-1_18121411_462.jpg
Survivin-antibody_WB_GTX28113-1_18121411_433.jpg

Cat No. GTX28113

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, IHC-P
Reactivity Mouse
APPLICATION

Application Note

For WB: Use at a dilution of 1:500-1:1,000. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

16 kDa. ( Note )

Positive Control

Mouse spleen cell lysate
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline, pH 7.4 containing 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

Synthetic peptide - amino acids 128-140 of Mouse Survivin

Purification

Affinity purified with antigen

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

AAC-11, Api4, TIAP, survivin40, AAC 11, AAC11

Cellular Localization

Cytoplasmic

Background

Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP (1-3). Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas (1,3).

Database

Research Area

DATA IMAGES
Survivin-antibody_IHC-P_GTX28113-1_18121411_462.jpg

GTX28113 IHC-P Image

Immunohistochemical staining of Survivin in mouse spleen with Survivin antibody (GTX28113)at 10μg/ml.

Survivin-antibody_WB_GTX28113-1_18121411_433.jpg

GTX28113 WB Image

Western blot analysis of Survivin in mouse spleen tissue lysate with Survivin antibody (GTX28113) at 1μg/ml. Positive control: Mouse spleen cell lysate.

Package List Price ($)
$ 329