*Optimal dilutions/concentrations should be determined by the researcher.
Not tested in other applications.
TAB1 tansfected 293T cell
Mouse, Rat, Chicken, Pig, Rhesus Monkey(>80% identity)
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
0.26mg/ml(Please refer to the vial label for the specific concentration.)
Recombinant protein encompassing a sequence within the center region of human TAB1. The exact sequence is proprietary.
Purified by antigen-affinity chromatography.
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
3'-Tab1 antibody, MAP3K7IP1 antibody, MGC57664 antibody, TAB1 antibody, transforming growth factor beta-activated kinase-binding protein 1 antibody, mitogen-activated protein kinase kinase kinase 7-interacting protein 1 antibody, TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 antibody, TAK1-binding protein 1 antibody, TGF-beta activated kinase 1/MAP3K7 binding protein 1 antibody
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]
GTX103200 ICC/IF Image
Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed HeLa, using TAB1(GTX103200) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with GTX11304 (Red) at 1:2000.
GTX103200 WB Image
Western Blot analysis of TAB1 expression in transfected 293T cell line by MAP3K7IP1 polyclonal antibody.
A: Non-transfected lysate.
B: TAB1 transfected lysate.
12% SDS PAGE
GTX103200 diluted at 1:500