GeneTex
United States (US)

TAB1 antibody

GTX31691_280_ICC-IF_20180221_18121410_917.jpg
GTX31691_279_ICC-IF_20180221_18121410_460.jpg
GTX31691_2859_WB_20180221_18121410_639.jpg

Cat No. GTX31691

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application WB, ICC/IF, ELISA
Reactivity Human, Mouse
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.5 - 2 μg/mL
ICC/IF 1 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

55 kDa. ( Note )

Positive Control

K-562 Cell Slide(GTX25535) , K562 Cell Lysate(GTX27911) , 3T3 Cell Lysate , 3T3/BALB Cell Slide
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

TAB1 antibody was raised against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1.The immunogen is located within amino acids 220 - 270 of TAB1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Tgf-Beta Activated Kinase 1 (Map3K7) Binding Protein 1,3'-Tab1,Map3K7Ip1,Tab1

Background

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES
GTX31691_280_ICC-IF_20180221_18121410_917.jpg

GTX31691 ICC/IF Image

ICC/IF analysis of K562 cells using GTX31691 TAB1 antibody.
Working concentration : 1 μg/ml

GTX31691_279_ICC-IF_20180221_18121410_460.jpg

GTX31691 ICC/IF Image

ICC/IF analysis of 3T3 cells using GTX31691 TAB1 antibody.
Working concentration : 2 μg/ml

GTX31691_2859_WB_20180221_18121410_639.jpg

GTX31691 WB Image

WB analysis of 3T3 cell lysate using GTX31691 TAB1 antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml

Package List Price ($)
$ 329