APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 0.5 - 2 μg/mL |
| 1 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
K-562 Cell Slide(GTX25535) , K562 Cell Lysate(GTX27911) , 3T3 Cell Lysate , 3T3/BALB Cell Slide
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
TAB1 antibody was raised against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1.The immunogen is located within amino acids 220 - 270 of TAB1.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
TGF-beta activated kinase 1 (MAP3K7) binding protein 1 , 3''-Tab1 , MAP3K7IP1
Background
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
|
GTX31691 ICC/IF Image
ICC/IF analysis of K562 cells using GTX31691 TAB1 antibody.
Working concentration : 1 μg/ml
|
|
|
GTX31691 WB Image
WB analysis of 3T3 cell lysate using GTX31691 TAB1 antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml
|
|
|
GTX31691 ICC/IF Image
ICC/IF analysis of 3T3 cells using GTX31691 TAB1 antibody.
Working concentration : 2 μg/ml
|
REFERENCE
There are currently no references for TAB1 antibody (GTX31691). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for TAB1 antibody (GTX31691). Be the first to share your experience with this product.
