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TAB2 antibody

Anti-TAB2 antibody used in Flow cytometry (FACS). GTX02891
Anti-TAB2 antibody used in IHC (Paraffin sections) (IHC-P). GTX02891
Anti-TAB2 antibody used in IHC (Paraffin sections) (IHC-P). GTX02891
Anti-TAB2 antibody used in Western Blot (WB). GTX02891

Cat. No. GTX02891

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, FACS, ELISA

Reactivity

 Human
Package
100 μl ($429)
See all TAB2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.25-0.5μg/ml
IHC-P 2-5μg/ml
FACS 1-3μg/1x10⁶ cells
ELISA 0.1-0.5μg/ml
Not tested in other applications.

Calculated MW

76 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

4mg Trehalose, 0.9mg NaCl, 0.2mg Na₂HPO₄

Preservative

0.01mg Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

E.coli-derived human TAB2 recombinant protein (Position: Q169-K522).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TGF-beta activated kinase 1 (MAP3K7) binding protein 2 , CHTD2 , MAP3K7IP2 , TAB-2

Cellular Localization

Membrane , Cytoplasm, cytosol ,

Background

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Database

Research Area

DATA IMAGES

Anti-TAB2 antibody used in Flow cytometry (FACS). GTX02891

GTX02891 FACS Image

FACS analysis of U87 cells using GTX02891 TAB2 antibody.
Blue : Primary antibody
Green : Isotype control
Red : Unlabelled cells
Antibody amount : 1μg/1x10⁶ cells

Anti-TAB2 antibody used in IHC (Paraffin sections) (IHC-P). GTX02891

GTX02891 IHC-P Image

IHC-P analysis of human rectal cancer tissue using GTX02891 TAB2 antibody.
Antigen retireval : Heat mediated antigen retrieval was performed in EDTA buffer (pH8.0, epitope retrieval solution)
Dilution : 2μg/ml

Anti-TAB2 antibody used in IHC (Paraffin sections) (IHC-P). GTX02891

GTX02891 IHC-P Image

IHC-P analysis of human rectal cancer tissue using GTX02891 TAB2 antibody.
Antigen retireval : Heat mediated antigen retrieval was performed in EDTA buffer (pH8.0, epitope retrieval solution)
Dilution : 2μg/ml

Anti-TAB2 antibody used in Western Blot (WB). GTX02891

GTX02891 WB Image

WB analysis of various samples using GTX02891 TAB2 antibody.
Lane 1 : HeLa whole cell lysate
Lane 2 : A549 whole cell lysate
Lane 3 : HepG2 whole cell lysate
Dilution : 0.5 μg/ml
Loading : 50μg per lane

REFERENCE

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Package List Price ($)
$ 429