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TAP1 antibody

Anti-TAP1 antibody used in Immunohistochemistry (IHC). GTX13516
Anti-TAP1 antibody used in Western Blot (WB). GTX13516
Anti-TAP1 antibody used in Immunohistochemistry (IHC). GTX13516
Anti-TAP1 antibody used in Immunohistochemistry (IHC). GTX13516

Cat. No. GTX13516

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IP, IHC

Reactivity

 Human, Rat
Package
50 μl ($399)
See all TAP1 products

APPLICATION

Application Note

ICC: Use at an assay dependent dilution. IP: Use at a dilution of 1/100. WB: Use at a dilution of 1/4000. Detects a band of approximately 70 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

87 kDa. ( Note )

Positive Control

HeLa cell lysate

PROPERTIES

Form

Liquid

Buffer

Serum

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Synthetic peptide: AKLVQRQMLGLQPA, corresponding to amino acids 735-748 of Human TAP1.

Purification

Whole antiserum

Conjugation

Unconjugated

RRID

AB_373231

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

transporter 1, ATP binding cassette subfamily B member , ABC17 , ABCB2 , APT1 , D6S114E , PSF-1 , PSF1 , RING4 , TAP1*0102N , TAP1N

Background

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

Database

Research Area

DATA IMAGES

Anti-TAP1 antibody used in Immunohistochemistry (IHC). GTX13516

GTX13516 IHC Image

IHC analysis: Human prostate tissue stained with TAP1, pAb at 1:100.

Anti-TAP1 antibody used in Western Blot (WB). GTX13516

GTX13516 WB Image

Western blot analysis of TAP1, pAb (GTX13516):
Lane 1: MW marker
Lane 2: A431 cell lysate
Lane 3: HeLa cell lysate

Anti-TAP1 antibody used in Immunohistochemistry (IHC). GTX13516

GTX13516 IHC Image

IHC analysis: Human uterus tissue stained with TAP1, pAb at 1:100

Anti-TAP1 antibody used in Immunohistochemistry (IHC). GTX13516

GTX13516 IHC Image

IHC analysis: Human tonsil tissue stained with TAP1, pAb at 1:100.

REFERENCE

Application Reference

Simone LC et al. Tissue Antigens 2012; 79 (4) : 249-62 Analysis of major histocompatibility complex class I folding: novel insights into intermediate forms.
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REVIEW

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Package List Price ($)
$ 399