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TBKBP1 antibody

Anti-TBKBP1 antibody used in Western Blot (WB). GTX85248
Anti-TBKBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85248
Anti-TBKBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85248

Cat. No. GTX85248

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all TBKBP1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

68 kDa. ( Note )

Positive Control

Rat Liver Tissue Lysate(GTX27943)

Product Note

This antibody is specific for Prosapip2 C-Terminus

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Prosapip2 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Prosapip2.The immunogen is located within amino acids 500 - 550 of Prosapip2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

TBK1 binding protein 1 , ProSAPiP2 , SINTBAD

Background

Prosapip2 (TBKBP1) is essential for signal transduction during viral infection thus plays a major role in the TNF/NF-kappaB pathway. It is an adaptor protein that constitutively binds TBK1 (TANK-binding kinase) and IKBKE and may play a role in antiviral innate immunity. Prosapip2 is a 615 amino acid adaptor protein belonging to the fibrillar collagen family, consisting of trimers of identical alpha 1 chains which are linked to each other by interchain disulfide bonds. It has a ubiquitous expression with highest levels in ovary, followed by the neuronal system. Prosapip2 binds to TBK1 and helps in the activation of IRF3 which controls the expression of antiviral genes during infection. Recent studies show that Prosapip2 is an interaction partner of ProSAP2/Shank3 and actin, suggesting a role as a linker molecule between postsynaptic density and the cytoskeleton.

Database

Research Area

DATA IMAGES

Anti-TBKBP1 antibody used in Western Blot (WB). GTX85248

GTX85248 WB Image

WB analysis of rat liver tissue lysate using GTX85248 TBKBP1 antibody.
Working concentration : 1 μg/ml

Anti-TBKBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85248

GTX85248 IHC-P Image

IHC-P analysis of rat liver tissue using GTX85248 TBKBP1 antibody.
Working concentration : 20 μg/ml

Anti-TBKBP1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85248

GTX85248 IHC-P Image

IHC-P analysis of rat liver tissue using GTX85248 TBKBP1 antibody.
Working concentration : 5 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399