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TCP1 epsilon antibody [PK/29/23/8d]

Cat. No. GTX75918

Host

 Rat

Clonality

 Monoclonal

Clone Name

 PK/29/23/8d

Isotype

 IgG2a

Application

 WB, IP, Gel supershift assays

Reactivity

 Human, Mouse, Rat, Rabbit, Bovine
Package
50 μg ($399)
See all TCP1 epsilon products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1/250-1/500
IP Assay dependent
Gel supershift assays Assay dependent

Note :

WB
This antibody detects a band of approximately 60kD in lysates of heat shocked HeLa cells.
Not tested in other applications.

Calculated MW

60 kDa. ( Note )

Product Note

This antibody binds to the canonical isoform 1, binding to the truncated isoform 2 has not been evaluated (UniProt : P48643).

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.0 mg/ml (Please refer to the vial label for the specific concentration.)

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

RRID

AB_383978

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

chaperonin containing TCP1 subunit 5 , CCT-epsilon , CCTE , HEL-S-69 , PNAS-102 , TCP-1-epsilon

Cellular Localization

Cytoplasm

Background

The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. [provided by RefSeq, Apr 2015]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399