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TEP1 antibody

Anti-TEP1 antibody used in Western Blot (WB). GTX48658

Cat No. GTX48658

Host

Rabbit

Clonality

Polyclonal

Isotype

IgG

Application

WB, ELISA

Reactivity

Human
Package
50 μg ($319)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1 - 2 μg/ml
ELISA 1:10000 - 1:40000
Not tested in other applications.

Calculated MW

290 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 and 0.01% (w/v) Sodium Azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the amino terminus of human telomerase associated protein 1 (TEP1).

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

telomerase associated protein 1 , TLP1 , TP1 , TROVE1 , VAULT2 , p240

Cellular Localization

Nucleus

Background

Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

Database

Research Area

DATA IMAGES

Anti-TEP1 antibody used in Western Blot (WB). GTX48658

GTX48658 WB Image

Western blot using GeneTex's Affinity Purified anti-TP1 antibody shows detection of a predominant band at ~240 kDa corresponding to TEP1 (arrowhead) in human kidney tissue lysate. The predicted MW of TEP1 is 290 kDa. TEP1 was detected using 1 μg/ml (lane A) and 2 μg/ml (lane B) concentrations of primary antibody.

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf