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TET1 antibody [N3C1]

KO/KD Orthogonal Overexpression
Anti-TET1 antibody [N3C1] used in Western Blot (WB). GTX124207
Anti-TET1 antibody [N3C1] used in Western Blot (WB). GTX124207
Anti-TET1 antibody [N3C1] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX124207
Anti-TET1 antibody [N3C1] used in Western Blot (WB). GTX124207
Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207
Anti-TET1 antibody [N3C1] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX124207
Anti-TET1 antibody [N3C1] used in Western Blot (WB). GTX124207
Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207
Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207
Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207
Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207
Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207

Cat. No. GTX124207

Reference 61
9

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IHC-Wm, IP, ChIP assay, IHC

Reactivity

 Human, Mouse, Rat, Monkey
Package
100 μl ($399)
See all TET1 products
PRODUCT

Summary

TET1 antibody recognizes TET1 protein, which is a methylcytosine dioxygenase that catalyzes the sequential steps of DNA demethylation. Expression of TET1 protein is spatiotemporally regulated during embryonic development. Abnormal TET1 activation is associated with cancer growth and metastasis.

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
ICC/IF 1:100-1:1000
IHC-P 1:100-1:1000
IHC-Wm Assay dependent
IP Assay dependent
ChIP assay Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

235 kDa. ( Note )

Positive Control

DDDDK-human TET1-transfected 293T , 293T , A431 , HeLa , HepG2

PROPERTIES

Form

Liquid

Buffer

1XPBS (pH7), 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.05 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human TET1. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_11176491

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

tet methylcytosine dioxygenase 1 , CXXC6 , LCX , bA119F7.1

Cellular Localization

Nucleus

Background

Dioxygenase that specifically binds methylcytosine (5mC), a minor base in mammalian DNA found in repetitive DNA elements that is crucial for retrotransposon silencing and mammalian development. Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. 5-hydroxymethylcytosine (hmC) is present in ES cells and is enriched in the brain, especially in Purkinje neurons. May play a role in the fetal development of heart, lung and brain.

Database

Research Area

DATA IMAGES

Anti-TET1 antibody [N3C1] used in Western Blot (WB). GTX124207

GTX124207 WB Image

KO/KD

Non-transfected (–) and transfected (+) 293T whole cell extracts (50 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with TET1 antibody [N3C1] (GTX124207) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-TET1 antibody [N3C1] used in Western Blot (WB). GTX124207

GTX124207 WB Image

Various whole cell extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with TET1 antibody [N3C1] (GTX124207) diluted at 1:2000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-TET1 antibody [N3C1] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX124207

GTX124207 ICC/IF Image

TET1 antibody [N3C1] detects TET1 protein at nucleus by immunofluorescent analysis.
Sample: Mock and transfected 293T cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: TET1 stained by TET1 antibody [N3C1] (GTX124207) diluted at 1:1000.
Blue: Hoechst 33342 staining.

Anti-TET1 antibody [N3C1] used in Western Blot (WB). GTX124207

GTX124207 WB Image

Orthogonal

HeLa whole cell and nuclear extracts (30 μg) were separated by 5% SDS-PAGE, and the membrane was blotted with TET1 antibody [N3C1] (GTX124207) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207

GTX124207 IHC-P Image

Immunohistochemical analysis of paraffin-embedded Hela xenograft, using TET1 (GTX124207) antibody at 1:1000 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-TET1 antibody [N3C1] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX124207

GTX124207 ICC/IF Image

TET1 antibody [N3C1] detects TET1 protein at cytoplasm and nucleus by immunofluorescent analysis.
Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min.
Green: TET1 stained by TET1 antibody [N3C1] (GTX124207) diluted at 1:500.
Red: alpha Tubulin, a cytoskeleton marker, stained by alpha Tubulin antibody [GT114] (GTX628802) diluted at 1:1000.
Blue: Fluoroshield with DAPI (GTX30920).

Anti-TET1 antibody [N3C1] used in Western Blot (WB). GTX124207

GTX124207 WB Image

Overexpression

TET1 antibody [N3C1] detects TET1 protein by western blot analysis.
A. 30 μg 293T whole cell lysate/extract
B. 30 μg whole cell lysate/extract of DDDDK-human TET1-transfected 293T cells
5% SDS-PAGE
TET1 antibody [N3C1] (GTX124207) dilution: 1:5000
The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.

Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207

GTX124207 IHC-P Image

TET1 antibody [N3C1] detects TET1 protein at nucleus on Human normal prostate tissue by immunohistochemical analysis.
Sample: Paraffin-embedded Human normal prostate tissue.
TET1 antibody [N3C1] (GTX124207) dilution: 1:1000.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207

GTX124207 IHC-P Image

TET1 antibody [N3C1] detects TET1 protein at nucleus in human A549 xenograft by immunohistochemical analysis.
Sample: Paraffin-embedded human A549 xenograft .
TET1 antibody [N3C1] (GTX124207) diluted at 1:250.

Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207

GTX124207 IHC-P Image

TET1 antibody [N3C1] detects TET1 protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded mouse testis.
TET1 stained by TET1 antibody [N3C1] (GTX124207) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207

GTX124207 IHC-P Image

TET1 antibody [N3C1] detects TET1 protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded rat testis.
TET1 stained by TET1 antibody [N3C1] (GTX124207) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207

GTX124207 IHC-P Image

TET1 antibody [N3C1] detects TET1 protein at nucleus by immunohistochemical analysis.
Sample: Paraffin-embedded mouse testis.
TET1 stained by TET1 antibody [N3C1] (GTX124207) diluted at 1:500.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

REFERENCE

Application Reference

Qu K et al. APL Bioeng 2023; 7 (3) : 36104 Oscillatory shear stress-induced downregulation of TET1s injures vascular endothelial planar cell polarity by suppression of actin polymerization.
van der Veer BK et al. Nucleic Acids Res 2023; 51 (11) : 5469-5498 Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation.
Li J et al. Nat Commun 2022; 13 (1) : 3907 TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation.
Application : WB
Reactivity : Human
Thaler R et al. Nat Commun 2022; 13 (1) : 5883 Vitamin C epigenetically controls osteogenesis and bone mineralization.
Application : WB
Reactivity : Mouse
Wu BK et al. Nat Genet 2022; 54 (8) : 1202-1213 YAP induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis.
Show More +
Submit a Reference

REVIEW

TET1 antibody [N3C1] Cat. No. GTX124207

Rating
( Average 5 based on 9 users reviews)
Application
Western Blot(WB)
( Average 5 based on 5 users reviews)
IHC (Paraffin sections)(IHC-P)
( Average 5 based on 2 users reviews)
ChIP assay(ChIP assay)
( Average 5 based on 1 users reviews)
Immunohistochemistry(IHC)
( Average 5 based on 1 users reviews)
Anti-TET1 antibody [N3C1] used in Western Blot (WB). GTX124207
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Int J Endocrinol in 2020.PMID: 32089682
Anti-TET1 antibody [N3C1] used in Western Blot (WB). GTX124207
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Int J Endocrinol in 2020.PMID: 32089682
Anti-TET1 antibody [N3C1] used in Western Blot (WB). GTX124207
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal BMC Cancer in 2018.PMID: 30045709
Anti-TET1 antibody [N3C1] used in Western Blot (WB). GTX124207
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Clin Epigenetics in 2016.PMID: 26973719
Anti-TET1 antibody [N3C1] used in Western Blot (WB). GTX124207
Date : Anonymous submitted on 10-Aug-2021
Score :
Application Tested : WB
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Clin Epigenetics in 2016.PMID: 26973719
Anti-TET1 antibody [N3C1] used in Immunohistochemistry (IHC). GTX124207
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : IHC
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Clin Epigenetics in 2018. PMID: 30075814
Anti-TET1 antibody [N3C1] used in ChIP assay (ChIP assay). GTX124207
Date : Anonymous submitted on 18-Mar-2021
Score :
Application Tested : ChIP assay
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Sci Rep in 2016. PMID: 27708396
Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207
Date : Anonymous submitted on 23-Dec-2020
Score :
Application Tested : IHC-P
Sample Species : Hu
Figure Note : The data was peer reviewed and published in the journal Clin Epigenetics in 2018. PMID: 30075814
Anti-TET1 antibody [N3C1] used in IHC (Paraffin sections) (IHC-P). GTX124207
Date : Anonymous submitted on 14-Oct-2016
Score :
Application Tested : IHC-P
Sample Species : Hu
Sample : human pancreatic ductal adenocarcinoma
Fixation : 10% paraformaldehyde
Primary Antibody : 1:200, 25°C, 2Hr
Show More +
Submit a Review
Application Reference
Qu K et al. APL Bioeng 2023; 7 (3):36104 Oscillatory shear stress-induced downregulation of TET1s injures vascular endothelial planar cell polarity by suppression of actin polymerization.
van der Veer BK et al. Nucleic Acids Res 2023; 51 (11):5469-5498 Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation.
Li J et al. Nat Commun 2022; 13 (1):3907 TET1 dioxygenase is required for FOXA2-associated chromatin remodeling in pancreatic beta-cell differentiation.
Application : WB
Reactivity : Human
Thaler R et al. Nat Commun 2022; 13 (1):5883 Vitamin C epigenetically controls osteogenesis and bone mineralization.
Application : WB
Reactivity : Mouse
Wu BK et al. Nat Genet 2022; 54 (8):1202-1213 YAP induces an oncogenic transcriptional program through TET1-mediated epigenetic remodeling in liver growth and tumorigenesis.
Kai Qu et al. Int J Biol Sci 2022; 18 (5):2163-2180 TET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis.
Application : WB
Benedict Shi Xiang Lian et al. iScience 2022; 25 (4):104118 Regulation of Il6 expression by single CpG methylation in downstream of Il6 transcription initiation site.
Application : IP
Lv J et al. Nat Cell Biol 2022; 24 (3):364-372 Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1-mucin pathway.
Application : ICC/IF
Reactivity : Mouse
Feng J et al. Stem Cell Res Ther 2022; 13 (1):29 Sin3a drives mesenchymal-to-epithelial transition through cooperating with Tet1 in somatic cell reprogramming.
Application : IP
Reactivity : Human
Shirui Huang et al. Cancer Cell Int 2021; 21 (1):241 miR-190 promotes malignant transformation and?progression of human urothelial cells through CDKN1B/p27 inhibition.
Application : WB
Reactivity : Human
Jody Ye et al. J Biol Chem 2021; 296:100774 Genetic and environmental factors regulate the type 1 diabetes gene CTSH via differential DNA methylation.
Application : WB
Reactivity : Human
Schagdarsurengin U et al. Clin Epigenetics 2021; 13 (1):211 Tracing TET1 expression in prostate cancer: discovery of malignant cells with a distinct oncogenic signature.
Application : WB, IHC-P
Reactivity : Human
Chu M et al. Front Cell Dev Biol 2021; 9:784244 Vitamin C Rescues in vitro Embryonic Development by Correcting Impaired Active DNA Demethylation.
Application : IHC-Wm
Reactivity : Mouse
Aggarwal RK et al. Proc Natl Acad Sci U S A 2021; 118 (39) Functional succinate dehydrogenase deficiency is a common adverse feature of clear cell renal cancer.
Application : WB
Reactivity : Human
Kawakubo-Yasukochi T et al. Mol Metab 2021; 54:101360 Hepatic glycogenolysis is determined by maternal high-calorie diet via methylation of Pygl and it is modified by oteocalcin administration in mice.
Application : ChIP assay
Reactivity : Mouse
Chen W et al. Cell Rep 2021; 37 (5):109912 Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring.
Application : WB
Reactivity : Mouse
Huang Z et al. Sci Adv 2021; 7 (4) The chromosomal protein SMCHD1 regulates DNA methylation and the 2c-like state of embryonic stem cells by antagonizing TET proteins.
Application : WB
Reactivity : Human
Lv H et al. Cell Metab 2021; 33 (1):110-127.e5 NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion.
Application : IHC-P, IP
Reactivity : Mouse
Patani H et al. Nat Commun 2020; 11 (1):3671 Transition to na?ve human pluripotency mirrors pan-cancer DNA hypermethylation.
Damal Villivalam S et al. Nat Commun 2020; 11 (1):4313 TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis.
Application : WB
Reactivity : Mouse
Gu Y et al. FASEB J 2020; (Epub) Hydrogen sulfide attenuates renal fibrosis by inducing TET-dependent DNA demethylation on Klotho promoter.
Application : IHC-P
Reactivity : Human
Wang J et al. Nutr Metab (Lond) 2020; 17:46 TET1 promotes fatty acid oxidation and inhibits NAFLD progression by hydroxymethylation of PPARα promoter.
Application : IHC-P
Reactivity : Mouse
Cao T et al. FASEB J 2020; 34 (6):8625-8640 H19/TET1 axis promotes TGF-β signaling linked to endothelial-to-mesenchymal transition.
Application : WB
Reactivity : Human
Yan YL et al. Front Oncol 2020; 10:667 Downregulation of TET1 Promotes Bladder Cancer Cell Proliferation and Invasion by Reducing DNA Hydroxymethylation of AJAP1.
Application : IHC-P
Reactivity : Human
Yu S et al. Int J Endocrinol 2020; 2020:3909610 TET1 is a Tumor Suppressor That Inhibits Papillary Thyroid Carcinoma Cell Migration and Invasion.
Application : WB
Reactivity : Human
Xu Y et al. Cell Rep 2020; 30 (5):1310-1318.e5 A Positive Feedback Loop of TET3 and TGF-β1 Promotes Liver Fibrosis.
Application : WB
Reactivity : Mouse
Wu J et al. J Exp Clin Cancer Res 2019; 38 (1):348 TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/帣-catenin signaling pathway to suppress EMT in pancreatic tumor cells.
Application : WB
Reactivity : Human
Volnitskiy A et al. PLoS One 2019; 14 (2):e0211980 Abnormal activity of transcription factors gli in high-grade gliomas.
Application : WB
Reactivity : Human
Pei YF et al. Am J Pathol 2019; (Epub) Methyl-CpG Binding Domain Protein 2 Inhibits the Malignant Characteristic of Lung Adenocarcinoma through the Epigenetic Modulation of 10 to 11 Translocation 1 and miR-200s.
Application : WB, IHC-P
Reactivity : Human
Ciccarone F et al. Mol Nutr Food Res 2019; 63 (4):e1800970 High Dietary Fat Intake Affects DNA Methylation/Hydroxymethylation in Mouse Heart: Epigenetic Hints for Obesity-Related Cardiac Dysfunction.
Application : WB
Reactivity : Mouse
Barazeghi E et al. BMC Cancer 2018; 18 (1):764 Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors.
Cheng Y et al. Cell Rep 2018; 25 (11):3194-3203.e4 Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice.
Chen YL et al. Am J Cancer Res 2018; 8 (12):2548-2563 Cellular 5-hydroxylmethylcytosine content determines tumorigenic potential and prognosis of pancreatic ductal adenocarcinoma.
Ma F et al. J Cell Physiol 2018; (Epub) LIN28A activates the transcription of NANOG in dairy goat male germline stem cells.
Application : ICC/IF
Reactivity : Human
Fan J et al. Clin Epigenetics 2018; 10 (1):103 TET1 exerts its anti-tumor functions via demethylating DACT2 and SFRP2 to antagonize Wnt/β-catenin signaling pathway in nasopharyngeal carcinoma cells.
Application : IHC-P
Reactivity : Human
Ai-hua Wu et al. Current Medical Science 2018; (38):505–512 Expression of TET and 5-HmC in Trophoblast Villi of Women with Normal Pregnancy and with Early Pregnancy Loss.
Application : WB
Atlante S et al. Cell Death Dis 2018; 9 (7):756 α-ketoglutarate dehydrogenase inhibition counteracts breast cancer-associated lung metastasis.
Application : WB, ICC/IF
Reactivity : Human
Adachi K et al. Cell Stem Cell 2018; (Epub) Esrrb Unlocks Silenced Enhancers for Reprogramming to Naive Pluripotency.
Application : ChIP assay
Zhou Y et al. Cell Physiol Biochem 2018; 45 (6):2548-2559 Ginsenoside 20(S)-Rg3 Inhibits the Warburg Effect Via Modulating DNMT3A/ MiR-532-3p/HK2 Pathway in Ovarian Cancer Cells.
Application : WB
Reactivity : Human
Good CR et al. Nucleic Acids Res 2017; 45 (14):8269-8281 A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer.
Zhu J et al. Sci Rep 2017; 7 (1):8077 Hypoxia-induced TET1 facilitates trophoblast cell migration and invasion through HIF1α signaling pathway.
Application : IHC-P
Reactivity : Human
Tovy A et al. Genes Dev 2017; (Epub) p53 is essential for DNA methylation homeostasis in naive embryonic stem cells, and its loss promotes clonal heterogeneity.
Application : WB
Reactivity : Mouse
Cleven AHG et al. Clin Sarcoma Res 2017; 7:8 IDH1 or -2 mutations do not predict outcome and do not cause loss of 5-hydroxymethylcytosine or altered histone modifications in central chondrosarcomas.
Application : IHC-P
Reactivity : Human
Chen H et al. Oncogene 2017; (Epub) Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice.
Application : WB
Reactivity : Mouse
Barazeghi E et al. Clin Epigenetics 2016; 8:31 5-Hydroxymethylcytosine discriminates between parathyroid adenoma and carcinoma.
Application : WB
Reactivity : Human
Chen Y et al. Adv Mater 2016; Genome-Wide DNA Methylation Variations upon Exposure to Engineered Nanomaterials and Their Implications in Nanosafety Assessment.
Application : WB
Reactivity : Human
Tian Y et al. Scand J Gastroenterol 2016;:43109 Association of TET1 expression with colorectal cancer progression.
Application : WB
Reactivity : Human
Zhang W et al. Sci Rep 2016; 6:34543 ERK/c-Jun Recruits Tet1 to Induce Zta Expression and Epstein-Barr Virus Reactivation through DNA Demethylation.
Application : WB
Reactivity : Monkey
Zhou FC et al. PLoS One 2016; 11 (9):e0162063 Cell-Wide DNA De-Methylation and Re-Methylation of Purkinje Neurons in the Developing Cerebellum.
Reactivity : Mouse
Yang YA et al. Nucleic Acids Res. 2016; FOXA1 potentiates lineage-specific enhancer activation through modulating TET1 expression and function.
Application : ICC/IF, IP
Reactivity : Human
Ni K et al. Hum Reprod 2016; (Epub) TET enzymes are successively expressed during human spermatogenesis and their expression level is pivotal for male fertility.
Application : WB, IHC-P
Reactivity : Human
Weber AR et al. Nat Commun 2016; 7:10806 Biochemical reconstitution of TET1-TDG-BER-dependent active DNA demethylation reveals a highly coordinated mechanism.
Application : IP
Reactivity : Human
Grosser C et al. Epigenetics 2015; 10 (9):819-33 Altering TET dioxygenase levels within physiological range affects DNA methylation dynamics of HEK293 cells.
Application : WB
Reactivity : Human
Ciccarone F et al. Oncotarget 2015; 6 (27):24333-47 5mC-hydroxylase activity is influenced by the PARylation of TET1 enzyme.
Application : WB, IP
Reactivity : Human
Ichimura N et al. Cancer Prev Res (Phila) 2015; 8 (8):702-11 Aberrant TET1 Methylation Closely Associated with CpG Island Methylator Phenotype in Colorectal Cancer.
Application : WB
Reactivity : Human
Rampal R et al. Cell Rep 2014; 9 (5):1841-1855 DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.
Ciccarone F et al. Oncotarget 2014; 5 (21):10356-67 Poly(ADP-ribosyl)ation is involved in the epigenetic control of TET1 gene transcription.
Application : WB
Reactivity : Human
Jin C et al. Nucleic Acids Res 2014; 42 (11):6956-71 TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells.
Application : WB
Reactivity : Human
Jefferson WN et al. Mol Endocrinol 2013; 27 (10):1666-77 Persistently altered epigenetic marks in the mouse uterus after neonatal estrogen exposure.
Application : WB
Reactivity : Mouse
Dong E et al. Transl Psychiatry 2012; 2:e159 Upregulation of TET1 and downregulation of APOBEC3A and APOBEC3C in the parietal cortex of psychotic patients.
Application : WB
Reactivity : Human
Hsu CH et al. Cell Rep 2012; 2 (3):568-79 TET1 suppresses cancer invasion by activating the tissue inhibitors of metalloproteinases.
Application : ChIP assay
Reactivity : Human
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