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TFE3 antibody [IHC672]

Anti-TFE3 antibody [IHC672] used in IHC (Paraffin sections) (IHC-P). GTX57200

Cat. No. GTX57200

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 IHC672

Isotype

 IgG1

Application

 IHC-P

Reactivity

 Human
Package
500 μl ($689)
See all TFE3 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P 1:100-1:200

Note :

IHC-P
Heat-induced epitope retrieval (HIER) at pH 9 for 10 - 30 minutes
Not tested in other applications.

Calculated MW

62 kDa. ( Note )

Positive Control

Testes, Melanoma, Xp11.2 Translocation Renal Cell Carcinoma

PROPERTIES

Form

Liquid

Buffer

Tris buffer, 1% BSA

Preservative

0.09% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant Human TFE3 protein.

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Transcription Factor Binding To Ighm Enhancer 3 , Rccp2 , Rccx1 , Tfea , Bhlhe33 , Tfe3

Background

The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1); it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion

Research Area

DATA IMAGES

Anti-TFE3 antibody [IHC672] used in IHC (Paraffin sections) (IHC-P). GTX57200

GTX57200 IHC-P Image

IHC-P analysis of human kidney tissue using GTX57200 TFE3 antibody [IHC672]

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 689