APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| Assay dependent |
| Assay dependent |
|
Note :
Sandwich ELISA
Capture: GTX03004, Detection: GTX03003-02.
|
Not tested in other applications.
Calculated MW
Product Note
This antibody is able to detect native and recombinant human latent Transforming Growth Factor-β1 (TGF-β1), binds to the Latency Associated Protein (LAP), which is a part of the latent TGF-β1 complex and does not bind to latent TGF-β2 or -β3.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.5 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Recombinant latent TGF-β1
Purification
Protein G purified
From tissue culture supernatant
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
CED,DPD1,LAP,TGFB,TGFB1,TGFbeta,transforming growth factor beta 1,TGF beta 1
Cellular Localization
Secreted,Extracellular space,Extracellular matrix
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
Database
Research Area
DATA IMAGES
![Anti-TGF beta 1 antibody [MT593] used in ELISA (ELISA). GTX03004](/templates/default/js/lightbox/images/loading.gif "Anti-TGF beta 1 antibody [MT593] used in ELISA (ELISA). GTX03004")
|
GTX03004 ELISA Image
Sandwich ELISA analysis of human Latent TGF- beta1 protein using GTX03004 TGF beta 1 antibody [MT593] as coating antibody and GTX03003-02 TGF beta 1 antibody [MT517] (Biotin) as detecting antibody.
Substrate : pNPP
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REFERENCE
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REVIEW
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![Anti-TGF beta 1 antibody [MT593] used in ELISA (ELISA). GTX03004](/upload/website/prouct_img/small/GTX03004/GTX03004_20210507_ELISA_w_23053123_112.webp "Anti-TGF beta 1 antibody [MT593] used in ELISA (ELISA). GTX03004")
![Anti-TGF beta 1 antibody [MT593] used in ELISA (ELISA). GTX03004](/upload/website/prouct_img/normal/GTX03004/GTX03004_20210507_ELISA_w_23053123_112.webp "Anti-TGF beta 1 antibody [MT593] used in ELISA (ELISA). GTX03004")