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United States (US)

TGF beta 1 antibody

Cat No. GTX10518

Host Chicken
Clonality Polyclonal
Isotype IgY
Application WB, Neut
Reactivity Human
Package
25 μg ($319)
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 0.1-0.2 ug/mL
Neut ND₅₀:5-30 ng/mL
Not tested in other applications.

Calculated MW

44 kDa. ( Note )

Specificity/Sensitivity

The antibody will neutralize the biological activity of recombinant human TGF-β1 and porcine TGF-β1.2.
PROPERTIES

Form

Liquid

Buffer

PBS, 5% trehalose

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

Recombinant human TGF-β1 expressed in CHO cells.

Purification

Purified by affinity chromatography

Endotoxin

< 0.1 EU/ug antibody

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Transforming Growth Factor Beta 1,Ced,Dpd1,Lap,Tgfb,Tgfbeta,Tgfb1

Background

Transforming Growth Factor Beta 1 is a multifunctional peptide capable of influencing cell proliferation, differentiation, and other functions in a wide range of cell types. Transformed as well as non-neoplastic tissues, release transforming growth factors; and essentially all cells possess a specific TGF beta 1 receptor. The multi-modal nature of TGF beta 1 is seen in its ability to stimulate or inhibit cellular proliferation. In general, cells of mesenchymal origin appear to be stimulated by TGF-Beta-1 whereas hepatocytes, T and B lymphocytes, keratinocytes and many epithelial cells are inhibited by the peptide. TGF beta 1 interacts with Epidermal Growth Factor, Platelet Derived Growth Factor, Fibroblast Growth Factor, and IL2 either by enhancing or antagonizing their characteristic actions. TGF beta 1 plays a fundamental role in tissue growth and differentiation involvement in adipogenesis, myogenesis, chondrogenesis, osteogenesis, epithelial cell differentiation and immune cell function.

Database

Research Area

REFERENCE
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REVIEW
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