APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1:500-1:1000 |
| 1:50-1:200 |
Not tested in other applications.
Calculated MW
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.05% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic peptide, corresponding to amino acids 341-390 of Human TGFβ1.
Purification
Purified by antigen-affinity chromatography
From serum
Purity
> 95% (by SDS-PAGE)
Conjugation
Unconjugated
Note
For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET
Synonyms
transforming growth factor beta 1 , CED , DPD1 , IBDIMDE , LAP , TGFB , TGFbeta
Background
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGFB family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease. [provided by RefSeq, Aug 2016]
Database
Research Area
DATA IMAGES
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GTX66628 WB Image
WB analysis of various samples using GTX66628 TGF beta 1 antibody.
Lane1 : HeLa cell lysate
Lane2 : SP2/0 cell lysate
Lane3 : H9C2 cell lysate
Lane4 : MCF-7 cell lysate
Dilution : 1:500
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GTX66628 WB Image
WB analysis of various samples using GTX66628 TGF beta 1 antibody.
Lane1 : L02 whole cell lysate(40ug)
Lane2 : HEK293T whole cell lysate(40ug)
Lane3 : AML-12 whole cell lysate(40ug)
Lane4 : H9C2 whole cell lysate(40ug)
Dilution : 1:500
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GTX66628 IHC-P Image
IHC-P analysis of human breast carcinoma tissue using GTX66628 TGF beta 1 antibody.
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REFERENCE
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REVIEW
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