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TGF beta Receptor 2 antibody [4F14]

Anti-TGF beta Receptor 2 antibody [4F14] used in IHC (Paraffin sections) (IHC-P). GTX52507

Cat. No. GTX52507

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 4F14

Isotype

 IgG1

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μg ($399)
See all TGF beta Receptor 2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:100 - 1:1000
IHC-P 1:50 - 1:200
Not tested in other applications.

Calculated MW

65 kDa. ( Note )

Product Note

No cross reactivity was found to TGF beta receptor 3

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant hu-TGFβRII extra cellular domain

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

AAT3 , FAA3 , LDS1B , LDS2 , LDS2B , MFS2 , RIIC , TAAD2 , TGFBR2 , TGFR2 , TGFbetaRII , transforming growth factor beta receptor 2 , TGF beta Receptor 2 , TGF beta Receptor II , TGF-beta RII

Cellular Localization

Cell membrane

Background

The protein encoded by this gene is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with TGF-beta receptor type-1, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of genes related to cell proliferation, cell cycle arrest, wound healing, immunosuppression, and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES

Anti-TGF beta Receptor 2 antibody [4F14] used in IHC (Paraffin sections) (IHC-P). GTX52507

GTX52507 IHC-P Image

IHC-P analysis of formalin fixed human placenta tissue using GTX52507 TGF beta Receptor 2 antibody [4F14].

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399